[Creation of monoclonal antibodies against tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor alpha (TFG-alpha), their definition and possible use].
Mots clés
Abstrait
These antibodies were characterised immunoserologically and immunohistochemically. The antibodies proved suitable in the detection of TNF-alpha and TGF-alpha production by different cells and tissues. These anti-TNF-alpha specific monoclonal antibodies were able to inhibit the cytotoxic effect of hrTNF-alpha in vitro. These monoclonal antibodies may potentially be useful in the future for determining TNF-alpha or TGF-alpha level by different immunodiagnostical assays (ELISA, RIA, FIA) in the medical practice.