Metabolites 2019-Oct
Hepatic Metabolic Derangements Triggered by Hyperthermia: An In Vitro Metabolomic Study.
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Abstrait
METHODS
In this study, gas chromatography-mass spectrometry (GC-MS)-based metabolomics was applied to assess the in vitro metabolic response of primary mouse hepatocytes (PMH, n = 10) to a heat stress stimulus, i.e., after 24 h exposure to 40.5 °C. Metabolomic profiling of both intracellular metabolites and volatile metabolites in the extracellular medium of PMH was performed.