Zhongguo yao li xue bao = Acta pharmacologica Sinica 1996-May
Inhibitory effect of quercetin on tumor necrosis factor and interleukin-1 beta pro-osteoclastic activities.
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Mots clés
Abstrait
OBJECTIVE
To study the effects of quercetin on tumor necrosis factor (TNF) and interleukin-1 beta (IL-1 beta) pro-osteoclastic activities.
METHODS
[3H] TdR uptake by osteoblasts was used to measure cell proliferation, microspectrophotometer for cellular AIP activity using p-nitrophenyl phosphate as enzyme substrate, and radioimmunoassay for prostaglandin E2.
RESULTS
Quercetin 5-40 mumol.L-1 reduced the inhibition of cell proliferation and AIP activity induced by TNF or IL-1 beta in a concentration-dependent manner. PGE2 production stimulated by either cytokines was also reduced by quercetin at 20 and 40 mumol.L-1.
CONCLUSIONS
quercetin exerted a marked inhibitory effect on TNF and IL-1 activities, related to their pro-osteoclastic function.
