Bioorganic and Medicinal Chemistry Letters 2011-Apr
Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists.
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Mots clés
Abstrait
The pharmacokinetic based optimisation of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB(1) receptor is disclosed. Compound 24 was found to be a highly potent and selective cannabinoid CB(1) antagonist with high predicted human oral bioavailability.