The antiinflammatory activity of extracts from the root of Combretum dolichopetalum.
Mots clés
Abstrait
The methanol and chloroform extracts of the root of Combretum dolichopetalum were obtained and gave yields of 6.48% w/w and 0.38% w/w respectively. The methanol extract significantly inhibited carageenin-induced mouse paw edema in a dose-dependent manner after an oral treatment. The maximum effect was achieved at a dose of 600 mg/kg and the result was comparable to that of indomethacin (10 mg/kg). The antiinflammatory activity of the chloroform extract against croton-oil induced mouse ear edema was significant (p < 0.001) and increased with the dose. The maximum effect (93%) was achieved with 1.0 mg of the extract per ear.