Effect of Tobacco Smoking on Outcomes after Left Ventricular Assist Device Implantation.

Despite the well-established correlation between tobacco use and cardiovascular disease, little is known about postoperative outcomes following left ventricular assist device (LVAD) implantation. We aimed to elucidate the effect of tobacco smoking on post-LVAD implant outcomes. Patients who received LVADs from 2013-2018 were retrospectively characterized as current, former, or never smokers at the time of implant. We examined one-year survival, total hospital readmissions, and specific hospital readmissions for LVAD-related adverse events based on patient's smoking status. Of the enrolled patients (n = 292), 55% were former smokers, 33% were never smokers, and 11% were current smokers. The majority of patients were African-American (48%) with a median age of 58 years. Never smokers were younger and less likely to be Caucasian compared to former or current smokers (p <0.05, for both). The category of former smokers had statistically comparable total readmission rates with never smokers (2.49 vs. 2.13 event/year), whereas current smokers had significantly higher rates compared to never smokers (2.81 events/year, p <0.05), with odds ratio 2.12 (95% CI 1.35-3.32) adjusted for age and Caucasian race for >5 times of total readmissions per year. The rates of driveline infection, stroke, and hemolysis were statistically comparable between never smokers and former smokers, while current smokers had significantly higher rates compared to never smokers (p <0.05 for all).