Journal of Pharmacy and Pharmacology 2020-Apr
Green synthesis of gold nanoparticles by using Ferula persica Willd. gum essential oil: production, characterization and in vitro anti-cancer effects.
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The absorption peak in UV-visible spectroscopy was at 530 nm. In TEM image, Au NPs were spherical in shape with average size of 37.05 nm (78.6 nm in DLS analysis). Comparison of the FTIR spectrum of the Au NPs with the essential oil revealed the presence of compounds responsible for reducing and capping the gold ions. XRD pattern showed metal crystal structure. Au NPs exerted dose-dependent cytotoxicity with IC50 values of 0.0024 and 0.0307 mg/ml against CT26 and Vero cell lines, respectively. Au NPs induced apoptosis on both cell lines with statistically more intense effect on CT26 cells (P < 0.0001). Colony formation of CT26 and Vero cells was also inhibited in comparison to untreated cells (P < 0.05).