Two new iridoid glycosides from the fruit of Gardenia jasminoides

Two new iridoid glycosides, 2'-O-cis-coumaroylgardoside (1), and 6'-O-caffeoylioxide (2), were isolated from the fruit of Gardenia jasminoides. The structures of these compounds were elucidated based on spectroscopic analysis (HR-ESI-MS, NMR) and chemical methods. The anti-inflammatory activities of the isolates were evaluated by measuring their inhibitory effects on PGE₂ production in LPS stimulated RAW 264.7 macrophages, compounds 1 and 2 could reduce PGE₂ levels in LPS-activated RAW 264.7 macrophages with IC₅₀ values of 121.4 and 83.38 μM, respectively.

Keywords: Gardenia jasminoides; 2′-O-cis-coumaroylgardoside; 6′-O-caffeoylioxide; PGE2; anti-inflammatory.