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1 4 naphthoquinone/hémorragie
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[Effect of 1,4-naphthoquinones on lipolysis in hemorrhagic shock].
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Derivatives of 1,4-naphthoquinones increased the lipolytic activity of epididymal and perinephric fatty tissues. A compound AK-45 Na at a dose of 30 mg/kg elevated the positive effect of rheopolyglucine on lipid metabolism, contributing to mobilization as well as to consumption of lipids in
[Correlation of immunomodulating effects induced by lysozyme and naphthoquinones in acute blood loss].
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The role of erythrocytes in realization of interrelation of the immunomodulating effects of lysozyme and naphthoquinones in normal and under conditions of acute hemorrhage was studied. Interaction of lysozyme and menadione at the level of intact erythrocytes and their stroma resulted in formation of
[Preventive treatment of hemorrhages in dentistry. B-naphthoquinone monosemicarbazone].
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[Effects of monosemicarbazone of beta naphthoquinone in experimental hemorrhagic shock].
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A hemorrhagic syndrome induced by derivatives of 3-hydroxy-1,4-naphthoquinone.
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Antagonism of the hemorrhagic syndrome induced by derivatives of 3-hydroxy-1,4-naphthoquinone.
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[Prevention of hemorrhage in prostatic surgery. Apropos of the study of the hemostatic activity in prostatectomy of a new molecule: beta-naphthoquinone monosemicarbazone (Naftazone)].
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Synthetic 1,4-pyran naphthoquinones are potent inhibitors of dengue virus replication.
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Dengue virus infection is a serious public health problem in endemic areas of the world where 2.5 billion people live. Clinical manifestations of the Dengue infection range from a mild fever to fatal cases of hemorrhagic fever. Although being the most rapidly spreading mosquito-borne viral infection
Studies on the antithrombotic and antiplatelet activities of NQ304, a newly synthesized naphthoquinone derivative.
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The effect of p6304 (2-chloro-3-(4-hexylphenyl)-amino-1,4-naphthoquinone) as a novel antithrombotic agent was investigated. NQ304 was found to inhibit platelet aggregation in human platelets in vitro and in rat ex vivo, and murine pulmonary thrombosis in vivo. NQ304 potently inhibited adenosine
Analgesic, anti-inflammatory, antipyretic and haematological effects of aethiopinone, an o-naphthoquinone diterpenoid from Salvia aethiopis roots and two hemisynthetic derivatives.
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Aethiopinone (1), an o-naphthoquinone diterpene from Salvia aethiopis L. roots and two hemisynthetic derivatives 2 and 3 have been evaluated for toxicity, anti-inflammatory, analgesic, antipyretic, and haemostatic activities. The compounds tested showed low toxicity and a pharmacological profile
Antiplatelet and antithrombotic activities of NQ301, 2-chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone.
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The antiplatelet and antithrombotic activities of a newly synthesized NQ301, 2-chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone, were investigated on human platelet aggregation in vitro and rats ex vivo, and murine pulmonary thrombosis in vivo. NQ301 potently inhibited ADP-, collagen-, epinephrine-
Modulation of plasminogen activator inhibitor-1 (PAI-1) by the naphthoquinone shikonin.
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Plasminogen activator inhibitor-1 (PAI-1) is a key negative regulator of the fibrinolytic system. Elevated levels of PAI-1 are associated with thrombosis and cardiovascular and metabolic diseases. Inhibition of PAI-1 activity represents a new strategy for antithrombotic and antifibrinolysis
Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms.
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The role of vitamins in hemostasis.
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The physiological mechanism to prevent and control abnormal bleeding is dependent on three vitamins (C, K, and Q). Two of these are unequivocally established as essential for hemostasis while the existence of the third (Q) is supported by experimental evidence and by clinical and therapeutic
Diospyros, an under-utilized, multi-purpose plant genus: A review.
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The genus Diospyros from family Ebenaceae has versatile uses including edible fruits, valuable timber, and ornamental uses. The plant parts of numerous species have been in use as remedies in various folk healing practices, which include therapy for hemorrhage, incontinence, insomnia, hiccough,
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