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11 résultats
LACTIC ACIDOSIS: A RARE MANIFESTATION OF SYNTHETIC MARIJUANA INTOXICATION.
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Synthetic cannabinoids are designer drugs that mimic the effect of cannabis, which has become popular with young drug users. These drugs have a similar chemical structure and pharmacologic effects as marijuana, but seem to be more potent. These substances have been banned by the US Drug Enforcement
ISMP Adverse Drug Reactions: Chronic Marijuana Use Associated With Recurrent Diabetic Ketoacidosis Lamotrigine-Induced Cataplexy Trimethoprim-Sulfamethoxazole-Induced Hyponatremia Ziprasidone-Induced Sleepwalking and Sleep-Related Eating Metabolic Acidosis Associated With Acetaminophen.
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The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to
A Case of Intussusception in a Patient with Marijuana Use: Coincidence or Possible Correlation?
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'Intussusception' means invaginating or telescoping and is caused by any condition that disrupts the normal physiological mechanism of intestinal peristalsis. Intussusception is rare in adults with an incidence of two to three cases per population of 1,000,000 annually. The most common cause of
The effects of marijuana smoke on gas exchange in ovine pregnancy.
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The effects of marijuana smoke on maternal respiratory rate and gas exchange were examined in nine chronically instrumented, late gestation ewes carrying singletons. The magnitude of exposure was randomly varied producing peak plasma levels of delta-9-tetrahydrocannabinol (delta-9-THC) ranging from
Cannabinoid receptor antagonist-induced striated muscle toxicity and ethylmalonic-adipic aciduria in beagle dogs.
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Ibipinabant (IBI), a potent cannabinoid-1 receptor (CB1R) antagonist, previously in development for the treatment of obesity, causes skeletal and cardiac myopathy in beagle dogs. This toxicity was characterized by increases in muscle-derived enzyme activity in serum and microscopic striated muscle
Suspected synthetic cannabinoid toxicosis in a dog.
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OBJECTIVE
To describe the effects of suspected synthetic cannabinoid (SC) toxicosis and the response to intravenous lipid emulsion (ILE) therapy in a dog.
METHODS
A 2-year-8-month-old male Boxer dog was evaluated at an emergency hospital for progressive ataxia and inappropriate mentation. The
Clinical toxicity following analytically confirmed use of the synthetic cannabinoid receptor agonist MDMB-CHMICA. A report from the Identification Of Novel psychoActive substances (IONA) study.
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BACKGROUND
Recreational use of Synthetic Cannabinoid Receptors Agonists (SCRAs) has become increasingly common in many countries and may cause severe toxic effects.
OBJECTIVE
To describe the clinical features of toxicity in seven men after analytically confirmed exposure to MDMB-CHMICA, a recently
Analysis of the respiratory effects of cannabinoids in rats.
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The objective of the present study was to evaluate the respiratory effects of cannabinoids and their influence on cardiovascular homeostasis.In spontaneously breathing urethane-anaesthetised rats, intravenous injection of the two synthetic cannabinoid receptor agonists WIN55212-2 and CP55940
Synthetic cannabinoid induced acute respiratory depression: Case series and literature review.
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Synthetic Cannabinoids are a street drug that is widely attainable and cheap compared to natural cannabis, and has variable potency and unpredictable effects with no commercially available diagnostic test to confirm its presence. Similar to natural cannabis, Synthetic Cannabinoid intoxication can
Human Toxicity Caused by Indole and Indazole Carboxylate Synthetic Cannabinoid Receptor Agonists: From Horizon Scanning to Notification.
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BACKGROUND
The emergence of novel psychoactive substances (NPS), particularly synthetic cannabinoid receptor agonists (SCRA), has involved hundreds of potentially harmful chemicals in a highly dynamic international market challenging users', clinicians', and regulators' understanding of what
Cannabinoids inhibit acid-sensing ion channel currents in rat dorsal root ganglion neurons.
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Local acidosis has been found in various pain-generating conditions such as inflammation and tissue injury. Cannabinoids exert a powerful inhibitory control over pain initiation via peripheral cognate receptors. However, the peripheral molecular targets responsible for the antinociceptive effects of
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