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Benzbromarone aggravates hepatic steatosis in obese individuals.
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As a widely used anti-gout drug, benzbromarone has been found to induce hepatic toxicity in patients during clinical treatment. Previous studies have reported that benzbromarone is metabolized via cytochrome P450, thus causing mitochondrial toxicity in hepatocytes. In this study, we found that
Bioassay screening of Amazonian plants.
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OBJECTIVE
The purpose of this study was to evaluate several biological activities of thirty plant extracts collected in the North West Amazon (Ecuador). Some of these plants are being used for their reputed medicinal properties by the natives of this region.
METHODS
Five in vitro bioassays were used
Low-Purine Diet Is More Effective Than Normal-Purine Diet in Reducing the Risk of Gouty Attacks After Sleeve Gastrectomy in Patients Suffering of Gout Before Surgery: a Retrospective Study.
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BACKGROUND
Obese patients with preoperative gout often suffer of gouty attacks after bariatric surgery (BS), probably due to the lack of an adequate postoperative diet.
OBJECTIVE
The objectives of the study are to assess whether sleeve gastrectomy (SG) is effective in reducing the frequency of gouty
Cherry consumption and decreased risk of recurrent gout attacks.
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OBJECTIVE
To study the relationship between cherry intake and the risk of recurrent gout attacks among individuals with gout.
METHODS
We conducted a case-crossover study to examine the associations of a set of putative risk factors with recurrent gout attacks. Individuals with gout were
Nocturnal risk of gout attacks.
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OBJECTIVE
Several plausible mechanisms and anecdotal descriptions suggest that gout attacks often occur at night, although there are no scientific data supporting this. We undertook this study to evaluate the hypothesis that gout attacks occur more frequently at night.
METHODS
We conducted a
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