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arginine/accident vasculaire cérébral
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Influence of Rivaroxaban for Intermittent Claudication and Exercise Tolerance in Patients With Symptomatic PAD
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EXISTING KNOWLEDGE AND MAIN ASSUMPTIONS OF THE PROJECT.
Atherosclerosis is the most common cause of peripheral artery disease (PAD). The first symptom of PAD is intermittent claudication (IC), which is characterized by the occurrence of pain, cramps, numbness, and discomfort in the lower limb
Exploring the Effect of Inorganic Nitrates on the Human Microvascular Physiology - a Pilot Study.
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Cardiovascular disease (CVD) is the largest cause of global mortality accounting for over twenty-nine percent of all deaths with coronary heart disease and stroke projected to become the global leading causes of mortality by 2020. Increased mortality represents only one side of the problem since the
L-Citrulline Dose Finding Safety Study in MELAS
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The human body is made of many cells and each cell contains many mitochondria. Mitochondria are called the powerhouses of the cell, because they produce the energy needed for a cell to be healthy and function the way it is meant to.
Diseases of the mitochondria affect the way the tissues and cells
Effects of Terlipressin on Management of Potential Organ Donors
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Thermodilution cardiac output was measured in triplicate. Hemodynamic parameters were calculated according to standard formulas.Oxygen delivery index (IDO2) was calculated as arterial oxygen content multiplied by CI. Systemic vascular resistance index (SVRI) was calculated as the MAP minus right
Effectiveness of Combined Aerobic and Strength Training in Acute and Chronic Adaptations in Patients With Heart Failure
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Literature Review:CHF is the major public health problem in the world[1], highly prevalent in older individuals and a major cause of disability, hospitalizations, morbidity and mortality[2]. Generally, CHF patients have reduced exercise capacity, with main symptoms of effort intolerance, early
Renoprotective Effects of Dapagliflozin in Type 2 Diabetes
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Study design A phase 4, monocenter, randomized, double-blind, comparator-controlled, parallel-group, mechanistic intervention trial to assess the effect of 12-week treatment with the sodium-glucose linked transporters (SGLT)-2 inhibitor dapagliflozin versus the sulfonylurea (SU) derivative
Neurological Prognostication of Patients in Therapeutic Hypothermia After Cardiac Arrest
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Neurological prognostication of patients in therapeutic hypothermia after cardiac arrest
Background: In Denmark, approximately 3000 people suffer from cardiac arrest (CA) each year. After CA with no blood flow for more than five minutes, cerebral ischemia, free radicals along with other mediators
Impact of Arterial Stiffness and Central Aortic Blood Pressure on Kidney Transplant Outcomes.
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Chronic kidney disease (CKD) is a significant public health problem in United States, particularly in southern states like Louisiana. People with CKD and end-stage renal disease (ESRD) have a poor survival compared with general population, and this is primarily due to a higher prevalence of
Study of Stroke Related Edema Treatments
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Previous work has demonstrated the pathophysiological role of arginine-vasopressin (AVP) in ischemic stroke. The mechanism of action of AVP is by 3 receptor subtypes: V1a, V1b and V2 expressed in brain, pituitary gland, myocardium, vasculature and kidneys. The role of the vasopressin receptors V1a
Angiogenesis and Fibrosis in Aortic Stenosis
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Integrins
Integrins are a group of molecules responsible for intercellular adhesion and signalling. They comprise a superfamily of heterodimeric receptors that are composed of 18 different α and β subunits. In combination, they can generate 24 different receptor subtypes with a range of
Angiogenesis and Fibrosis in Myocardial Infarction
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Integrins are a group of molecules responsible for intercellular adhesion and signalling. They comprise a superfamily of heterodimeric receptors that are composed of 18 different α and β subunits. In combination, they can generate 24 different receptor subtypes with a range of physiological and
68Ga-BNOTA-PRGD2 PET/CT in Evaluation of Stroke
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Integrin αvβ3 is an important member of this receptor family and expressed preferentially on regenerative vascular endothelial cells, but not or very low on the quiescent vessel cells and other normal cells. The αvβ3 integrin is a key mediator of angiogenesis and thus may be an important diagnostic
L-arginine Therapy on Endothelium-dependent Vasodilation & Mitochondrial Metabolism in MELAS Syndrome
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We will study a family of 3 siblings, each with different severities of MELAS, using safe, non-invasive tests. We will determine whether there is a decrease in the ability of small brain blood vessels to increase blood flow by dilating in response to certain stimuli such as increased blood carbon
Human Adaptation to High Altitude
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Study aim A: Red cell mass and hypoxia:
Various forms of altitude training have been used to increase in particular endurance performance of elite athletes. The most commonly used approaches is either to live and train at altitude (Live high - train high; LHTH) or to live at high altitude while
Administrating Oxytocin to Treat Treatment Schizophrenia and Schizo-affective Patients
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Social disability is a hallmark of schizophrenia, and improving social functioning in schizophrenia should improve patients' overall functioning and quality of life. Oxytocin (Granholm, McQuaid et al.) is a nine amino-acid neuropeptide synthesized in the hypothalamus, has found to modulate social
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