8 mg dexamethasone, single preoperative infusion

Complication, Postoperative

10 mg/kg methylprednisolone mixed in 100 ml NaCl (sodium chloride), infusion over 30 minutes, prior to surgery

Methylprednisolone

Dexamethasone mixed in 100 ml NaCl, infusion over 30 minutes, prior to surgery

Dexamethasone

Rigshospitalet

Preoperative High Dose Steroids for Liver Resection- Effect on Complications in the Immediate Postoperative Period

High Dose Steroids for Liver Resection - Effect on Complications and Endothelial Function in the Immediate Postoperative Phase - a Randomized, Doubleblind, Controlled Trial

Number of patients with any complication at any time, during stay in the PACU. Complications according to DASAIMS discharge criteria (modified Aldrete criteria)

Amount of endothelial markers (Syndecan-1, soluble thrombomodulin, SE-Selectin, vascular endothelial growth factor (VEGF) )

Number of patients with post-operative cognitive impairment, according to 3-minute diagnostic confusion assessment method (3D-CAM)

every 60 minutes, during stay in PACU. Numeric Rating Scale (NRS 0-10)

During admission, self reported. Numeric Rating Scale (NRS 0-10)

During admission, self reported. (Light, none, moderate, heavy nausea)

All analgesics other than standard medication, during admission. From Medical record.

All antiemetics other than standard medication, during admission. From Medical record.

impact on ALAT (alanin-aminotransferase) post surgery

impact on INR (International Normalized Ratio) post surgery

Kristin Julia Steinthorsdottir

Principal Investigator

Rigshospitalet, Denmark

Patients with severe alcoholic hepatitis and good response to therapy.

Patients with severe alcoholic hepatitis and poor response to therapy, that are not candidates to transplantation, according to the specified criteria.

Patients with severe alcoholic hepatitis and poor response to therapy, that are candidates to transplantation, according to the specified criteria.

Alcoholic Hepatitis

Hospital Central de Asturias

Hospital Marqués de Valdecilla

Hospital Clínico Universitario de Santiago

Hospital Puerta de Hierro

Clínica Universidad de Navarra

Hospital Vall d'Hebrón

Hospital Reina Sofía

Hospital Virgen de la Nieves

Complejo Hospitalario Universitario de la Coruña

Hospital Gregorio Marañón

Hospital Ramón y Cajal

Hospital Virgen de la Arrixaca

Hospital Carlos Haya

Hospital Virgen del Rocío

Hospital La Fe

Hospital Río Hortega

Hospital Lozano Blesa

Liver Transplantation in Alcoholic Hepatitis

Applicability of Liver Transplantation in Alcoholic Hepatitis

The survival of patients transplanted with alcoholic hepatitis is going to be compared with the survival of patients with alcoholic hepatitis that are not considered adequate for liver transplantation

The applicability of liver transplantation is defined as the ratio between the number of patients transplanted for alcoholic hepatitis and the number of patients with severe alcoholic hepatitis that do not respond to steroid therapy.

Proportion of patients who are accepted as candidates for liver transplantation who die before transplantation.

Proportion of patients transplanted for alcoholic hepatitis that have a recurrence in alcohol consumption

ascites/− nicotine

Preoperative High Dose Steroids for Liver Resection- Effect on Complications in the Immediate Postoperative Period

Liver Transplantation in Alcoholic Hepatitis

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