Individuals will perform a Modified Balke Treadmill test with no mask and their estimated VO2 peak will be calculated based off of peak workload.

Individuals will perform a Modified Balke Treadmill test while wearing a N-95 Respirator and their estimated VO2 peak will be calculated based off of peak workload.

Individuals will perform a Modified Balke Treadmill test while wearing a cloth mask and their estimated VO2 peak will be calculated based off of peak workload.

COVID-19

N-95 mask will be worn as personal protective equipment during a graded exercise test

N-95 Respirator

A cloth mask will be worn as personal protective equipment during a graded exercise test

Cloth Face Mask

No personal protective equipment during a graded exercise test

Graded exercise test

Cleveland Clinic

Effects of a N95 Respirator vs Cloth Mask on Exercise Capacity During Treadmill Exercise.

To gain further understanding on effects exercising with a cloth mask has on exercise capacity. Our working hypothesis is that wearing a face mask will limit exercise capacity by a minimal clinically important difference (MCID) of 1 estimated Metabolic Equivalent (eMET 3.5 O2 ml/kg/min).

Debasis Sahoo

Staff Physician

The Cleveland Clinic

These individuals will receive standard of care for post operative recovery following a prostatectomy.

These individuals will receive post operative physical therapy in addition to standard of care for post operative recovery following a prostatectomy.

Prostate Cancer

Physical therapy 1-2 times per week for 3 months postoperatively to include lifestyle education, manual therapy, and exercise.

Physical Therapy

Jennifer Stone

Pelvic Health and Physical Therapy to Improve Lives of Prostate Cancer Patients Undergoing Prostatectomy

Pelvic Health and Physical Therapy to Improve Lives of Prostate Cancer Patients

Change in IPPS from preoperative through to 18 months post operatively, assessed at intervals

Change in IIEF from preoperative through to 18 months post operatively, assessed at intervals

Change in NIH-CPSI from preoperative through to 18 months post operatively, assessed at intervals

Change in Pain VAS from preoperative through to 18 months post operatively, assessed at intervals

Change in BDI from preoperative through to 18 months post operatively, assessed at intervals

Change in Bristol Stool Scale from preoperative through to 18 months post operatively, assessed at intervals

Change in strength from preoperative through to 18 months post operatively, assessed at intervals

Jennifer Y Stone

Manager, Clinical Rehabilitative Services

University of Missouri-Columbia

Randomization into treatment and standard of care groups. Treatment group will receive physical therapy in addition to standard of care treatment.

flecainide x 6 months, then crossover to sotalol x 6 months

sotalol x 6 months, then crossover to flecainide x 6 months

Atrial Fibrillation

flecainide up to 150mg twice daily for the control of atrial fibrillation

Flecainide

sotalol up to 120mg twice daily for the control of atrial fibrillation

Sotalol

Jesse Brown VA Medical Center

Rush University Medical Center

University of Illinois at Chicago

Advocate Christ Medical Center

Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

A Prospective, Multi-Center, Randomized, Open Label Trial to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs

Subjects will be monitored with the Medtronic Reveal LINQ Insertable Cardiac Monitor (ICM) system to assess AF burden. The device will be programmed to optimize the memory for storing AF episode..

Quality of life assessment: Patients will be asked to fill out the AFEQT quality of life questionnaire baseline (study randomization), two, four, six, eight, ten, and 12 months (completion of the study). The questionnaire at the end of the 6rd month will be administered just prior to stopping the first study drug. The validated questionnaire is comprised of 20 questions about AF symptoms with answers given on a Likert scale. The questionnaire will be provided to the patients in paper format either in person or by mail, as applicable. A follow-up phone call will be made to each patient to ensure that the questionnaire is completed and returned.

atrioventricular block/fièvre

Effects of a N95 Respirator vs Cloth Mask on Exercise Capacity During Treadmill Exercise.

Pelvic Health and Physical Therapy to Improve Lives of Prostate Cancer Patients Undergoing Prostatectomy

Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

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