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Utility of Primary Glioblastoma Cell Lines
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Glioblastoma (GBM) is the most aggressive type of brain tumor arising from glial cells accounting for 52% of all parenchymal brain cancer cases and 20% of all intracranial tumors. GBM has pronounced mitotic activity, substantial tendency toward neoangiogenesis (microvascular proliferation),
Diabetes and Lipid Accumulationand Heart Transplant
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BACKGROUND Heart failure (HF) is an increasing disease, with a prevalence and incidence of about 1% and 0.15% of the general population respectively, affecting at least 300,000 patients in the USA. However, in cases of advanced heart failure, refractory to maximal medical therapy, and to devices
Recovery and Lifespan of Red Blood Cells From Pathogen-reduced, Stored Blood Units
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Each subject will receive one infusion of autologous, radiolabeled and BioRBC labeled INTERCEPT RBCs (Test RBCs) and one infusion of autologous BioRBC labeled untreated RBCs (Control RBCs) concomitantly. Each infusion will be approximately 20 mL, i.e., 10 mL of 51-chromium labeled RBC, and 10 mL of
Epigenetic Biomarker for Osteosarcoma
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The investigator want to enroll 100 osteosarcoma participants initially treated in Musculoskeletal Tumor Center of Peking University People's Hospital(PKUPH). All those participants will follow the chemo-protocol for osteosarcoma in PKUPH.8 ml of peripheral blood would be drawed before each cycle of
Safety, Tolerability, PK, Dosimetry, MTD and Preliminary Efficacy of Intra-lesionally Injected AvidinOX, Followed by IV Escalating Doses of [177Lu]DOTA-biotin in Pts With Injectable Solid Tumors or Lymphomas
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The primary objectives of this study are:
1. To identify the Maximum Tolerated Dose (MTD) of two consecutive repeated IV 177Lu-ST2210 administration following a previous tumor intra-lesion/s injection of AvidinOX.
2. To assess safety and tolerability of intra-lesionally injected AvidinOX + IV
Role of CD133 & Microsatellite Status in Evaluation of Rectosigmoid Cancer Young Adults Received Neoadjuvant Treatment
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The age incidence of colorectal cancer is above fifty years old world wide .But, when comparing the incidence and clinicopathological features of colorectal cancer in western countries and countries with constrained resources as Egypt , there is significant lower median age of incidence. In Egypt
Estimation of Interleukin-21 Levels in Gingival Crevicular Fluid in Patients With Periodontal Health and Disease Following Non-surgical Periodontal Therapy: A Clinico-biochemical Study
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Introduction
Periodontal disease is a poly-microbial disease that affects tooth-supporting tissues.1 Integral part of periodontal disease involves destruction of periodontal tissues that results from stimulation of the bacterial challenge to host immune-inflammatory response. Chronic periodontitis
Can Dietary Phytoestrogens Slow Down Prostate Tumor Proliferation?
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Data from ecologic and experimental studies clearly show a protective effect of dietary phytoestrogens against prostate cancer. Genetic factors are also of etiologic importance in prostate cancer and there is growing evidence for the importance of a gene-diet interaction in prostate cancer
Immunological and Oxidative Stress Response in Relation to Abdominal Cancer Surgery
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Background
The perioperative period is relatively short, but highly critical for cancer related survival. The surgical procedure results in release of tumor cells locally and in the blood, and induction of a surgical stress response (SSR). This leads to paralysis of the immune system, reduced
CD34+ Selected ASCT for Aggressive Lymphomas
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Background and rationale: Autologous stem cell transplantation (ASCT): High-dose chemotherapy (HDCT) followed by ASCT is considered the treatment of choice for relapsed/refractory lymphomas. On the basis of the results of the PARMA study group trial, high-dose chemotherapy followed by ASCT has
Anti-CD20 Radioimmunotherapy Before Chemotherapy and Stem Cell Transplant in Treating Patients With High-Risk B-Cell Malignancies
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PRIMARY OBJECTIVES:
I. To estimate the maximum tolerated dose (MTD) of 90Y activity that can be delivered via pretargeted radioimmunotherapy (PRIT) using B9E9-fusion protein (B9E9-FP), clearing agent (CA), and radiolabeled tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-biotin when followed
Hormone Replacement Therapy on the Postmenopausal Endometrium
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Subjects
Healthy postmenopausal women, amenorrheic for 1-10 years, aged 45-60 years and in use of follicle stimulating hormone > 30 mille-International unit/milliliters (mIU/mL), will participate in the study.
All women will be informed about the trial and signed the informed consent documents,
Effect of Nonsurgical Periodontal Therapy Verses Oral Hygiene Instructions on Patients With Chronic Periodontitis
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Subjects with moderate to advanced chronic periodontitis were selected for this longitudinal randomized clinical trial. Ethical clearance for the study was granted by the Medical Ethics Committee, Faculty of Dentistry, University of Malaya [Medical Ethics Committee Number: DF PE1002/0045(P)]. The
AvidinOX + [177Lu]DOTA-biotin (or 177Lu-ST2210) Complex in Patients With Liver Metastases From Colorectal Cancer
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Primary objectives
1. To identify the Maximum Tolerated Dose (MTD) of 177Lu-ST2210 after prior intra-lesional injection of AvidinOX in the liver.
2. To assess safety and tolerability of intra-lesionally injected AvidinOX + IV injected 177Lu-ST2210
3. To evaluate intra-lesional distribution and
Exercise-induced Bronchoconstriction in School Children
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Methods:
Patients and Study design It will be two-step study carried out among school teenagers. In the first step the school children will be screened for EIB during physical education (PE) lesson. Inn all children before and after physical exercise (PE) lesson spirometry will be performed.
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