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Page 1 de 24 résultats
Biotin compounds for targetting tumors and sites of infection
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BACKGROUND OF THE INVENTION
High contrast imaging of tumors can be achieved by allowing a nonradiolabeled antibody to localize and clear from the circulation prior to administration of a low molecular weight, radiolabeled moiety with high affinity for the pretargeted antibody (Paganelli, G. et al.,
Biotinidase-resistant biotin-DOTA conjugates
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TECHNICAL FIELD
The present invention relates to methods, compounds, compositions and kits useful for delivering to a target site a targeting moiety that is conjugated to one member of a ligand/anti-ligand pair. After localization and clearance of the targeting moiety conjugate, direct or indirect
Biotinidase resistant biotin-DOTA conjugates
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TECHNICAL FIELD
The present invention relates to methods, compounds, compositions and kits useful for delivering to a target site a targeting moiety that is conjugated to one member of a ligand/anti-ligand pair. After localization and clearance of the targeting moiety conjugate, direct or indirect
Method for immunoselection of cells using avidin and biotin
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TECHNICAL FIELD
This invention relates to methods of immunoselection employing avidin-biotin.
BACKGROUND OF THE INVENTION
Immunoselection is a generic term that encompasses a variety of techniques in which the specificity of a selection system is conferred by an antibody or an antibody-like molecule
Method for immunoselection of cells using avidin and biotin
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TECHNICAL FIELD
This invention relates to methods of immunoselection employing avidin-biotin.
BACKGROUND OF THE INVENTION
Immunoselection is a generic term that encompasses a variety of techniques in which the specificity of a selection system is conferred by an antibody or an antibody-like molecule
Method for immunoselection of cells using avidin and biotin
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TECHNICAL FIELD
This invention relates to methods of immunoselection employing avidin-biotin.
BACKGROUND OF THE INVENTION
Immunoselection is a generic term that encompasses a variety of techniques in which the specificity of a selection system is conferred by an antibody or an antibody-like molecule
Methods of targeting T-cells to tumors
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FIELD OF THE INVENTION
This invention pertains to novel immunological methods related to selective targeting of T-cells to cancer cells with antibodies, and methods of administering such antibodies.
BACKGROUND OF THE INVENTION
Within the next decade, cancer is likely to replace heart disease as the
Bacterium-based microrobot capable of targeting cancer tissue
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CROSS-REFERENCE TO RELATED APPLICATION
This application claims priority to Korean Patent Application No. 2012-0082536 filed on Jul. 27, 2012 and all the benefits accruing therefrom under 35 U.S.C. .sctn. 119, the contents of which are incorporated by reference in their entirety.
BACKGROUND
The
Photosensitizers with ligand targeting properties for tumor therapy
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to photodynamic therapy and chemotherapy, wherein a "parachute" structure is used to deliver a therapeutic agent to a defined subcellular location, and therefore the action of the therapeutic agent, such as
Composition and method for tumor imaging
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FIELD OF THE INVENTION
This invention relates to a method for enhancing transmembrane transport of exogenous molecules. More particularly, the use of nutrient receptors, including biotin or folate receptors, and the respective associated receptor mediated endocytotic mechanism associated with such
Biotin esters of rapamycin
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BACKGROUND OF THE INVENTION
This invention relates to biotin derivatives of rapamycin and a method for using them for inducing immunosuppression; in the treatment of transplantation rejection, host vs. graft disease, autoimmune diseases, diseases of inflammation, solid tumors, fungal infections,
Method for distinguishing normal and cancer cells
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BACKGROUND OF THE INVENTION
The present invention concerns the detection of exposed nuclear DNA. More especially, this invention concerns a method to diagnose cancer by determining the presence or absence of exposed nuclear DNA in cells and to monitor the progress of cancer therapy. The present
Aminoderivative of biotin and their conjugates with macrocyclic chelating agents
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TECHNICAL FIELD
The invention described herein relates to modified biotins useful for the preparation of conjugates with radionuclides for use in human and animal diagnostics and therapy, particularly for the diagnosis and treatment of pathological conditions such as tumours.
The invention described
Micronutrient formulations for radiation applications
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BACKGROUND OF THE INVENTION
Field of the Invention
This invention relates to a use of micronutrient formulations to reduce the effects of radiation on humans.
Description of the Related Art
Ionizing radiation (X-rays and gamma rays) has proven to be a double-edged sword in clinical Medicine since
Method and compositions for the detection of protein glycosylation
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BACKGROUND OF THE INVENTION
Field of the Invention
The invention relates to labeling, detecting, and/or isolating proteins with post-translational modifications.
Description of the Related Art
Protein glycosylation is one of the most abundant post-translational modifications and plays a fundamental
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