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calcinosis/solanum
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Enzootic calcinosis in horses grazing Solanum glaucophyllum in Argentina.
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Solanum glaucophyllum, a toxic plant known for its calcinogenic effects, causes enzootic calcinosis in ruminant and monogastric animals. We describe an outbreak of enzootic calcinosis that occurred in a herd of 110 horses grazing pastureland heavily contaminated with S. glaucophyllum in Buenos Aires
Solanum torvum as a causative agent of enzootic calcinosis in Papua, New Guinea.
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Inclusion of dried powdered leaves of Solanum torvum Swartz (collected in Papua, New Guinea) in the diet of rats induced hypercalcaemai rapidly and hyperphosphataemia more slowly; soft tissue calcification was most evident in the kidney and lung. Solanum torvum may be a causative agent of enzootic
Enzootic calcinosis in ruminants: A review
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Enzootic calcinosis (EC), is a chronic disease, caused by toxic plants, which has mainly affected ruminants for more than 100 years. It is characterized by a soft tissue calcification, hypercalcemia, hyperphosphatemia, hypoparathiroidism, hypercalcitoninism, osteonecrosis, and osteopetrosis. The
[Cattle calcinosis in Austria. IV. Comparative experimental studies on Ca and P metabolism in guinea pig following hypervitamonosis D and poisoning with Solanum malacoxylon].
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Calcinogenic factor in Solanum malacoxylon: evidence that it is 1,25-dihydroxyvitamin D3-glycoside.
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After glycosidic cleavage of the water-soluble vitamin D-like principle of the calcinogenic plant Solanum malacoxylon, the active lipophilic portion was purified by column chromatography and analyzed by combined gas chromatography and mass spectrometry. It was identified as 1,25-dihydroxyvitamin D3,
A case of solanum malacoxylon toxicity in pigs.
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The postmortem and histological changes seen in the kidneys, lungs and vascular system in spontaneous Solanum malacoxylon poisoning on a pig farm in Buenos Aires Province, Argentina, are reported. Macroscopic calcified plaques in the endocardium, aorta, and pulmonary artery and mineralization in
Modification by rumen of vitamin D-like activity of Solanum malacoxylon in rats.
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The biological activity of aqueous extracts of Solanum malacoxylon (SM) and of extracts preincubated with ruminal fluid (SMRF) on calcium and phosphate metabolism in vitamin D depleted rats was compared. The responses in intestinal 32P and 45Ca absorption, measured in an isolated duodenal loop in
Solanum malacoxylon: a toxic plant which affects animal calcium metabolism.
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The "enteque seco" is a disease of calcinosis, i.e., pathological deposition of calcium phosphate in soft tissues, which occurs in grazing cattle in Argentina and is of considerable economic importance. The ingestion of leaves of Solanum malacoxylon has been identified as the cause of the disease.
Screening of Vitamin D activity (VDA) of Solanum glaucophyllum leaves measured by radioimmunoassay (RIA).
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The ingestion of Solanum glaucophyllum (SG) causes a calcinosis of cattle named Enteque Seco (ES). The toxic principle is the 1,25-(OH)(2)D(3), mainly conjugated as glycoside. This study aims to validate a simple novel method of evaluation of the VDA of SG leaves. Aqueous extracts of SG were
Studies on the 1alpha, 25-dihydroxycholecalciferol-like activity in a calcinogenic plant. Cestrum diurnum, in the chick.
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Cestrum diurnum (day-blooming jessamine) has been proposed to cause calcinosis in horses and cattle in Florida. The present studies investigated some physiological properties of the plant, using the chick as the experimental animal. The inclusion of dried leaf powder in a rachitogenic diet restored
Paneth cells: histochemical and morphometric study in control and Solanum glaucophyllum intoxicated rabbits.
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The intestinal epithelium has a critical roll in host defence. One specialised cell type involved in this function is the Paneth cell, which secretes many substances with antimicrobial properties in response to different stimuli. Under pathological conditions, changes in the Paneth cell number,
[The Solanum molacoxylon: from the toxic plant to the therapeutic agent (author's transl)].
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The solanum molacoxylon (SM) is a plant which grows in South America, whose leaves produce a calcinosis on animal farms. In the aquous extract of the leaves a glycoside of 1, 25 (OH)2D3 has been found. The aquous extracts of the leaves of SM provokes an increase of intestinal calcium absorption
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