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cerebroside/nécrose
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Conversion of labelled cerebrosides in adult rabbit brain, local brain necrosis, autolysis series and in brain homogenate.
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[Roentgenologic characteristics of Gaucher's disease (author's transl)].
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Gaucher's disease is a rare metabolic disorder in which there is an abnormal accumulation of cerebrosides in the reticuloendothelial system due to a deficit of beta-glucuronidase. Three patients with this disease, 8, 14, and 23 years old, were studied. The purpose of this paper is to point out some
Increased red blood cell aggregation in patients with Gaucher disease is non-inflammatory.
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Red blood cell (RBC) aggregation is enhanced in the presence of ongoing inflammation, because of plasma protein effects, especially fibrinogen. Large RBC aggregates, in addition to being a marker of systemic inflammation, may hinder tissue perfusion and oxygenation. Gaucher disease, the most common
Glycosphingolipids from Sphingomonas paucimobilis induce monokine production in human mononuclear cells.
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Glycosphingolipids (GSL) isolated from the gram-negative lipopolysaccharide (LPS)-free bacterium Sphingomonas paucimobilis have remarkable structural similarities with LPS and its hydrophobic part, termed lipid A. Like LPS, but in contrast to the structurally related ceramides and cerebrosides, GSL
Neuroprotective effect of CPCGI on Alzheimer's disease and its mechanism.
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Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder causing progressive memory loss and cognitive impairment. The aberrant accumulation of amyloid‑β (Aβ) and neuroinflammation are two major events in AD. Aβ‑induced neurotoxicity and oxidative stress are also involved in the
Modeling and quantifying biochemical changes in C6 tumor gliomas by Fourier transform infrared imaging.
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The purpose of the study was to investigate molecular changes associated with glioma tissues using FT-IR microspectroscopic imaging (FT-IRM). A multivariate statistical analysis allowed one to successfully discriminate between normal, tumoral, peri-tumoral, and necrotic tissue structures. Structural
Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology.
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The "sphingosin" backbone of sphingolipids was so named by J. L. W. Thudichum in 1884 for its enigmatic ("Sphinx-like") properties. Although still an elusive class of lipids, research on the involvement of sphingolipids in the signal transduction pathways that mediate cell growth, differentiation,
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