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Gangrenous cheilitis associated with all-trans retinoic acid therapy for acute promyelocytic leukemia.
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A 67-year-old Japanese woman who presented with erythema on the abdomen and pancytopenia was found to have acute promyelocytic leukemia (APL). A skin biopsy revealed invasion of APL cells. She was started on induction treatment with all-trans retinoic acid (ATRA) at 45 mg/m(2). On day 4, the
[Cheilitis granulomatosa Melkersson-Rosenthal syndrome].
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Melkersson-Rosenthal syndrome is a rare disorder characterized by a triad of recurrent orofacial swelling, recurrent paralysis of the facial nerve and lingua plicata. The complete triad only occurs in 25% of MRS cases. Monosymptomatic or oligosymptomatic variants are more frequent; other findings
[Stomatitis, cheilitis and conjunctivitis after a common cold].
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A 24-year-old female patient complained of odynophagy, rhinitis, general apathy and fever (38.5 degrees C) which had persisted for 5 days. Treatment had initially been a combination of paracetamol, ibuprofen and acetylsalicylic acid and when no improvement occurred amoxicillin was prescribed.
[Vemurafenib-induced toxic epidermal necrolysis].
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BACKGROUND
Herein we report the first case of toxic epidermal necrolysis (TEN) occurring with use of vemurafenib.
METHODS
A 75-year-old female patient was being treated with vemurafenib for stage IV melanoma with BRAF V600E mutation. She suddenly presented fever, diffuse pruriginous maculopapular
[Parvovirus B19 primo-infection and cold agglutinins].
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BACKGROUND
Parvovirus B19 infection is frequent. Primary infection leads to diverse skin manifestations including the recently described gloves-and-socks papulopurpura.
METHODS
A patient presented with a papulopurpuric eruption on the nose, hands, feet and perineum with cheilitis and high-grade
[Cutaneous manifestations of Kawasaki disease. Apropos of 30 cases].
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A series of 30 cases of Kawasaki disease has been studied retrospectively over a period of 11 years. The aim was to reassess the diagnostic value of the dermatological manifestations. A modification of the extremities was observed in 28 patients (23 had early inflammatory lesions, 25 had late
[Clinical study of S-6437 in pediatrics (author's transl)].
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Clinical study of sustained release cephalexin (granules, 200 mg/g, S-6437) was conducted in pediatric patients as follows: 1. For infants under 20 kg of body weight, 25 approximately 50 mg/kg/day of this preparation (or 50 approximately 100 mg/kg/day for severe diseases) were given in two divided
[Kawasaki syndrome].
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Kawasaki disease or mucocutaneous lymph-node syndrome has been described in Japan in 1967. Diagnostic criteria are clinical. The diagnosis must be evoked when a child less than 5-year-old has fever lasting for 5 days or more, particularly if associated with conjonctivitis, cheilitis, rash, or
Vitamin A toxicity secondary to excessive intake of yellow-green vegetables, liver and laver.
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We report a case of sudden onset of vitamin A poisoning. A 20-year-old Japanese woman had been eating pumpkin and only a very limited amount of other foods on a daily basis for 2 years. She was overly concerned about weight reduction. Aurantiasis cutis and abnormal liver function tests were noted by
Remission induction of ANLL with low dose cytosine arabinoside combined with retinoic acid.
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Fourteen cases of acute non-lymphocytic leukemia (ANLL) were treated with low doses of cytosine arabinoside (LDAra-C 20 mg/m/q12h) and etretinate (all-trans-9-3, 7-dimethyl-2, 4, 6, 8 non-atetraenoate, 75 mg/d). Of which 9 were untreated, 3 were in first relapse and 2 were refractory patients. Five
[Adult Kawasaki disease].
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BACKGROUND
Kawasaki disease is an acute vasculitis seen rarely in adults. Diagnosis is based on fever lasting at least 5 days and four or five major clinical criteria in the absence of any other potential pathological causes.
METHODS
A 50-year-old woman taking no new medications immediately
A phase I trial and pharmacokinetic evaluation of CI-980 in patients with advanced solid tumors.
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CI-980 is a synthetic mitotic inhibitor that binds to the colchicine binding site of tubulin. It demonstrates broad activity against human and murine tumor models and shows no cross resistance with tumor models whose mechanism of resistance is mediated by P-glycoprotein (MDR-1). A phase I study was
Candidiasis
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Candidiasis is an opportunistic infection caused by Candida, a type of fungi. Fungi are eukaryotic organisms found in the form of yeasts, molds, or dimorphic fungi. Candida is a form of yeast. Candidiasis occurs most commonly as a secondary infection in immunocompromised individuals. Synonyms
Prevalence and factors associated with late HIV diagnosis.
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While highly active antiretroviral therapy has been successful in delaying progression into AIDS, late HIV diagnosis remains a major contributor to the mortality and morbidity of AIDS. An epidemiological study was conducted to evaluate the prevalence and factors of late diagnosis and the
Prosthetic Oral Rehabilitation of a Child With S-ECC: A Case Report with Histopathologic Analysis.
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The aim of this case report is to describe the treatment planning of a young child with severe early childhood caries (S-ECC) as well as the prosthetic rehabilitation technique. A 3-year-old female child was referred to the pediatric dentistry clinic with the chief complaint of tooth pain,
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