Children born from mothers treated with biologic drugs (with or without immunomodulators) at any time during pregnancy or the three months before conception. Biologic drugs are IgG monoclonal antibodies able to cross the placenta.

Children born from mothers treated with immunomodulators (without biologics) during pregnancy or the three months before conception.

Children born from mothers treated neither with biologic drugs nor with immunomodulators at any time during pregnancy or the three months before conception.

Inflammatory Bowel Diseases

Pregnancy

Complejo Hospitalario Santiago de Compostela

Hospital Universitario Reina Sofía

Hospital Clínico Universitario San Cecilio

Hospital Infanta Elena

Hospital Universitario Juan Ramón Jimenez

Hospital Regional Universitario de Málaga

Hospital Universitario Virgen de la Victoria

Hospital San Juan de Dios del Aljarafe

Hospital Universitario Virgen del Rocío

Hospital San Jorge

Hopsital Universitario Miguel Servet

Hospital Clínico Universitario Lozano Blesa

Hospital Royo Villanova

Hospital Universitario Central de Asturias

Hospital Universitario de Son Espases

Hospital Doctor Negrin

Hospital Universitario de Canarias

Hospital Universitario Nuestra Señora de la Candelaria

Hospital Universitario Marqués de Valdecilla

Hospital General de Castellon

Hospital Alcázar de San Juan

Hospital General de Tomelloso

Hospital General Universitario de Ciudad Real

Hospital Virgen de la Salud

Hospital Santos Reyes

Hospital Universitario de Burgos

Hospital Universitario de Salamanca

Hospital Clínico de Valladolid

Hospital Provincial de Zamora

Hospital Virgen de la Concha

Hospital del Mar

Hospital Universitario Clinic i Provincial

Hospital Universitario de Bellvitge

Hospital Vall d´Hebron

Hospital Universitari Dr Josep Trueta

Hospital Sant Joan de Déu

Consorci Sanitari de Terrassa

Hospital Joan XXIII

Hospital Universitari Sant Joan de Reus

Hospital General Universitario de Alicante

Hospital Marina Baixa de Villajoyosa

Hospital Universitario San Juan

Hospital General Universitario de Valencia

Hospital Lluis Alcanyís de Xátiva

Hospital Universitàri i Politècnic La Fe

Hospital San Pedro Alcántara

Complejo Hospitalario Universitario de Ferrol

Complexo Hospitalario Universitario de A Coruña

Complexo Hospitalario Universitario de Ourense

Hospital Alvaro Cunqueiro

Hospital Comaral de Inca

Hospital Universitario Fundación Alcorcón

Hospital Universitario de Fuenlabrada

Hospital Universitario Puerta de Hierro

Hosptial Universitario Infanta Cristina

Hospital del Henares

Hospital Universitario de Torrejón

Complejo Hospitalario de Navarra

Hospital de Galdakao-Usansolo

Hospital Universitario de Álava

Hospital Universitario de Donostia

Hospital de Granollers

Hospital Universitario de La Princesa

Hospital Clínico San Carlos

Hospital Universitario de La Paz

Hospital Universitario Doce de Octubre

Hospital Universitario Gregorio Marañón

Hospital Universitario Infanta Leonor

Hospital Universitario Infanta Sofía

Hospital Universitario Rey Juan Carlos

Hospital Universitario Virgen de la Arrixaca

Hospital Universitario Virgen del Rosell

Hospital Clínico Universitario de Valencia

Safety of IBD Drugs During Pregnancy and Breastfeeding: Mothers and Babies' Outcomes (DUMBO Registry)

To assess the prevalence of complications related to drugs used for IBD treatment for pregnancy.

To assess the prevalence of complications related to drugs used for IBD treatment for the offspring.

To asses the prevalence of complications related to drugs used for IBD treatment for pregnancy.

To asses the prevalence of complications related to drugs used for IBD treatment for offspring mainly focused on the risck of serious infections at the age of 4 years.

To know the risk of serious adverse events (including abortions) during pregnancy and delivery associated with drugs used for the treatment of IBD.

To asses the developmental status of children born from IBD mothers during the first 4 years.

To compare the relative risk of serious adverse events in children born from mothers with IBD who have been exposed in utero to different drugs to treat IBD with the risk in children who were not exposed.

To compare the prevalence of malformations in children exposed to biologics to treat IBD in utero with the prevalence in children who were not exposed

To evaluate the relative risk of developing neoplasm in children exposed to drugs to treat IBD.

Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa

Spanish Agency of Medicines and Health Products

neonates diagnosed with Sepsis and will receive melatonin. 10 mg product as a total dose of 20 mg .together with conventional treatment of Neonatal sepsis

neonates diagnosed with Sepsis and willnot receive melatonin., they will recieve only the conventional treatment of Neonatal Sepsis

healthy neonates, in whom sepsis will be ruled-out on the basis of absence of any clinical or laboratory evidence suggestive of infection.

Neonatal Sepsis

Melatonin will be given at a total dose of 20 mg dissolved in 4 ml of distilled water via enteral route in two doses of 10 mg each(2 ml ), with a 1-hour interval. to one group together with conventional treatment

Melatonin 10 mg

Conventional treatment of neonatal sepsis including antibiotics,IV fluids, Total Parenteral Nutrition,etc...

Conventional treatment of neonatal sepsis

Effects of Melatonin as a Novel Antioxidant and Free Radicals Scavenger in Neonatal Sepsis

efficacy of melatonin as an adjuvant in the treatment of free radical disease in septic preterms receiving melatonin compared to those on conventional treatment through measuring the level of Malondialdehyde as a marker of oxidative stress

efficacy of melatonin as an adjuvant in the treatment of septic preterms compared to those on conventional treatment and by comparing other clinical and laboratory parameters of sepsis in both groups

Mohamed Hussein Metwally

Assistant Lecturer

a single dose of carbetocin (100 μg in 1 mL ampoule, Pabal) given intravenously after delivery of anterior shoulder

misoprostol (600 μg, 3 tables) sublingually after the delivery of the anterior shoulder of the baby.

Severe Pre-eclampsia, Postpartum Condition or Complication

given after the delivery of the anterior shoulder of the baby.

misoprostol

given after delivery of anterior shoulder

chorioamnionitis/crise épileptique

Safety of IBD Drugs During Pregnancy and Breastfeeding: Mothers and Babies' Outcomes (DUMBO Registry)

Effects of Melatonin as a Novel Antioxidant and Free Radicals Scavenger in Neonatal Sepsis

Prevention of Postpartum Hemorrhage in Patients With Severe Preeclampsia Using Carbetocin Versus Misoprostol

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