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Antimalarial activity of Cinchona-like plants used to treat fever and malaria in Brazil.
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For centuries, malaria was treated with the bark of Cinchona calisaya and Cinchona succirubra plants named "quinas" in Brazil, from which the quinine molecule was isolated. Other plant species known also as "quinas" are used to treat fever and malaria, like Deianira erubescens (roots and leaves),
Cinchona Febrifuge in Malarious Fevers.
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Observations on the Action of the Darjeeling Cinchona Febrifuge in Malarious Fevers.
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Correspondence Relating to the Use of "Cinchona Febrifuge" in the Treatment of Periodic Fevers.
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Treatment and Statistical Details of the Treatment of 600 Cases of Malarious Fever in the Bhopal Battalion Hospital by Cinchona Febrifuge or Mixed Alkaloids.
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An Empire's Extract: Chemical Manipulations of Cinchona Bark in the Eighteenth-Century Spanish Atlantic World.
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In 1790, the Spanish Crown sent a "botanist-chemist" to South America to implement production of a chemical extract made from cinchona bark, a botanical medicament from the Andes used throughout the Atlantic World to treat malarial fevers. Even though the botanist-chemist's efforts to produce the
Bitter plants used as substitute of Cinchona spp. (quina) in Brazilian traditional medicine.
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BACKGROUND
Bitter tasting plant species are used as tonics and have been previously used to treat intermittent fevers in Brazil, the principal symptom of malaria. Many of these species were named quina and were used as substitutes of Cinchona spp., the source of quinine.
OBJECTIVE
To present data on
Science in the service of colonial agro-industrialism: the case of cinchona cultivation in the Dutch and British East Indies, 1852-1900.
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The isolation of quinine from cinchona bark in 1820 opened new possibilities for the mass-production and consumption of a popular medicine that was suitable for the treatment of intermittent (malarial) fevers and other diseases. As the 19th century European empires expanded in Africa and Asia,
Combination of quinine, quinidine and cinchonine for the treatment of acute falciparum malaria: correlation with the susceptibility of Plasmodium falciparum to the cinchona alkaloids in vitro.
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Thirteen patients with acute symptomatic uncomplicated falciparum malaria were enrolled in an open, randomized, phase 2, dose-finding clinical trial of a fixed dosage combination of quinine, quinidine and cinchonine (LA40221, Sanofi Recherche, France), which contained equal parts of the 3 alkaloids
Medicinal plants used in the treatment of Malaria: A key emphasis to Artemisia, Cinchona, Cryptolepis, and Tabebuia genera.
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Malaria is one of the life-threatening parasitic diseases that is endemic in tropical areas. The increased prevalence of malaria due to drug resistance leads to a high incidence of mortality. Drug discovery based on natural products and secondary metabolites is considered as alternative approaches
Intrarectal Quinimax (an association of Cinchona alkaloids) for the treatment of Plasmodium falciparum malaria in children in Niger: efficacy and pharmacokinetics.
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In an attempt to avoid the complications associated with intramuscular quinine administration, we assessed the intrarectal route. Sixty-six children aged from 2 to 10 years with Plasmodium falciparum malaria were included in the study, which took place in Niamey, Niger. Fifty-five children were
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