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colorectal neoplasms/l tyrosine
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Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
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BACKGROUND OF THE INVENTION
The process of signal transduction in cells is responsible for a variety of biological functions including, but not limited to, cell division and death, metabolism, immune cell activation, neurotransmission, and sensory perception to name but a few. Accordingly,
Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
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BACKGROUND OF THE INVENTION
The process of signal transduction in cells is responsible for a variety of biological functions including, but not limited to, cell division and death, metabolism, immune cell activation, neurotransmission, and sensory perception to name but a few. Accordingly,
Tyrosine kinome
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A portion of the disclosure of this patent document contains material which is subject to copyright protection. The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or the patent disclosure, as it appears in the Patent and Trademark Office patent file
Tyrosine kinome
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A portion of the disclosure of this patent document contains material which is subject to copyright protection. The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or the patent disclosure, as it appears in the Patent and Trademark Office patent file
Tyrosine kinome
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A portion of the disclosure of this patent document contains material which is subject to copyright protection. The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or the patent disclosure, as it appears in the Patent and Trademark Office patent file
Protein tyrosine phosphatase mutations in cancers
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This application incorporates a 502 KB text file named "seqlst00631" created Jul. 22, 2010, which is the sequence listing for this application.
TECHNICAL FIELD OF THE INVENTION
This invention is related to the area of cancer. In particular, it relates to diagnosis, prognosis, treatment, drug
Protein tyrosine phosphatase mutations in cancers
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TECHNICAL FIELD OF THE INVENTION
This invention is related to the area of cancer. In particular, it relates to diagnosis, prognosis, treatment, drug discovery, target discovery, clinical testing for cancer.
BACKGROUND OF THE INVENTION
Phosphorylation of tyrosine residues is a central feature of most
Antibodies
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on May 11, 2016, is named OTJ_009US_Sequence.txt and is 27,712 bytes in
Pyrido[2,3-b]pyrazin-8-substituted compounds and their use
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TECHNICAL FIELD
The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin-8-substituted compounds, as described herein, which, inter alia, inhibit RAF (e.g., B-RAF)
Pyrido[2,3-B]pyrazin-8-substituted compounds and their use
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TECHNICAL FIELD
The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin-8-substituted compounds, as described herein, which, inter alia, inhibit RAF (e.g., B-RAF)
Pyrido[2,3-B]pyrazin-8-substituted compounds and their use
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RELATED APPLICATION
This application is related to U.S. provisional patent application No. 61/015,019 filed 19 Dec. 2007, the contents of which are incorporated herein by reference in their entirety.
TECHNICAL FIELD
The present invention pertains generally to the field of therapeutic compounds for
Pyrido[2,3-b]pyrazin-8-substituted compounds and their use
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TECHNICAL FIELD
The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin-8-substituted compounds, as described herein, which, inter alia, inhibit RAF (e.g., B-RAF)
Aryl-quinolyl compounds and their use
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TECHNICAL FIELD
The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain aryl-quinolyl compounds, as described herein, which, inter alia, inhibit RAF (e.g., B-RAF) activity. The present
Pyrido[2,3-b]pyrazin-8-substituted compounds and their use
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TECHNICAL FIELD
The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin-8-substituted compounds, as described herein, which, inter alia, inhibit RAF (e.g., B-RAF)
Imidazo[4, 5-B]pyridin-2-one and oxazolo[4, 5-B] pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds
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RELATED APPLICATIONS
This application is a national stage filing under 35 U.S.C. 371 of International Application No. PCT/GB2007/001534 filed 26 Apr. 2007, which is related to: United Kingdom patent application number 0608268.9 filed 26 Apr. 2006 and U.S. patent application No. 60/745,633 filed 26
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