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cryptococcosis/hypoxie
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Hypoxia sensing in cryptococcus neoformans: biofilm-like adaptation for dormancy?
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BACKGROUND
Cryptococcus neoformans is an obligate aerobic pathogenic yeast causing lung infection typically followed by spread to the central nervous system. During pathogenesis, it relies on well-established virulence factors. This review focuses on the emerging role of cryptococcal adaptation to
Massive pulmonary cryptococcosis in an immunocompetent patient.
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A 64-year-old man presented with progressive dyspnea. The symptom of severe hypoxia requiring mechanical ventilator, and bilateral pulmonary infiltrates on the chest film led to the clinical diagnosis of adult respiratory distress syndrome. Autopsy demonstrated widespread cryptococci and mucinous
Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype.
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Metabolically quiescent pathogens can persist in a viable non-replicating state for months or even years. For certain infectious diseases, such as tuberculosis, cryptococcosis, histoplasmosis, latent infection is a corollary of this dormant state, which has the risk for reactivation and clinical
Multiple opportunistic fungal infections in an individual with severe HIV disease: A case report.
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BACKGROUND
Fungal infections have been commonly diagnosed in individuals with advanced HIV disease. Cryptococcosis, pneumocystosis, and histoplasmosis are the most frequent systemic mycoses in people suffering from HIV/AIDS.
METHODS
We report a case of multiple fungal infections in an advanced
Cryptococcal pneumonia complicating pregnancy.
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In the present report we describe 4 previously healthy women who developed cryptococcal pneumonia during pregnancy, and 1 pregnant woman with cryptococcal meningitis. These cases illustrate a previously uncharacterized spectrum of cryptococcal disease. We also discuss 24 patients previously reported
Landmark Clinical Observations and Immunopathogenesis Pathways Linked to HIV and Cryptococcus Fatal Central Nervous System Co-Infection
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Cryptococcal meningitis remains one of the leading causes of death among HIV-infected adults in the fourth decade of HIV era in sub-Saharan Africa, contributing to 10%-20% of global HIV-related deaths. Despite widespread use and early induction of ART among HIV-infected adults, incidence of
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