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cryptosporidiosis/phosphatase
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A study on experimental cryptosporidiosis.
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Cryptosporidium oocysts were isolated from stools of infected patients diagnosed as cryptosporidiosis. Suckling Swiss albino mice were infected orally by these oocysts in a dose of 10(6) oocysts/mouse. Mice were divided into 9 groups according to the duration of infection 2, 3, 4, 5, 6, 7, 10, 10,
Intestinal cryptosporidiosis: pathophysiologic alterations and specific cellular and humoral immune responses in rnu/+ and rnu/rnu (athymic) rats.
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In order to develop an experimental model of symptomatic cryptosporidiosis in an immunosuppressed mammal, we investigated the pathophysiology of infection with Cryptosporidium and the humoral and cellular host responses in rnu/rnu (athymic) rats and their heterozygous (rnu/+) littermates by
Cellular Identification and In Silico Characterization of Protein Phosphatase 2C (PP2C) of Cryptosporidium parvum.
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Infection dynamics and clinical features of cryptosporidiosis in SCID mice.
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Cryptosporidial infections in severe combined immune deficient (SCID) mice produce a chronic disease state which in the later stages leads to extraintestinal involvement and hepatic dysfunction. To further characterize the infection dynamics in this model and monitor the changes in the hepatic
Natural history of AIDS related sclerosing cholangitis: a study of 20 cases.
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A case control study of AIDS related sclerosing cholangitis indicates that it has no overall influence on prognosis, but is responsible for a striking reversal of the usual inverse correlation of age and survival in HIV infection. Pain, the principal symptom, was controlled in surviving patients
Novel and promising compounds to treat Cryptosporidium parvum infections.
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No fully effective approved drug therapy exists for Cryptosporidium infections of immunocompetent and immunocompromised patients. Here, we investigated 11 benzimidazole derivatives carrying substituted thioalkyl and thiobenzyl groups at position 2 of benzimidazole nucleus and additional substituents
Detection of Cryptosporidium-specific serum immunoglobulins in captive snakes by a polyclonal antibody in the indirect ELISA.
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An indirect enzyme-linked immunosorbent assay (ELISA) was developed for the detection of systemic Cryptosporidium-specific antibodies (Ab) in the serum of captive snakes. An optimal concentration of Cryptosporidium soluble protein-cocktail antigen was 20 micrograms/mL. In a direct ELISA, alkaline
[Non-viral liver infections in immunocompromised patients].
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Bacterial, parasitic and fungal liver infections have been reported in severely immunocompromized patients. The liver is usually involved when the infection is disseminated. Clinical manifestations are non specific and commonly associated with increased in alcaline phosphatases serum level. Liver
Impairment of amino-acid absorption in suckling rats infected with Cryptosporidium parvum.
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In the present study. we explored the nutritional consequences of cryptosporidiosis. In order to ascertain the direct responsibility of C. parvum for impairment of staturoponderal development observed during the infection in neonatal animals, we investigated the absorption of two major components of
Sclerosing cholangitis in acquired immunodeficiency syndrome. Case reports and review of the literature.
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Four patients with acquired immunodeficiency syndrome (AIDS) (CDC group IV) were investigated for biliary disease because of the presence of both severe upper abdominal pain and raised levels of serum alkaline phosphatase. None was clinically jaundiced. Upper abdominal ultrasound was abnormal in
Efficacy of pyrvinium pamoate against Cryptosporidium parvum infection in vitro and in a neonatal mouse model.
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No effective approved drug therapy exists for Cryptosporidium infection of immunocompromised patients. Here we investigated the nonabsorbed anthelmintic drug pyrvinium pamoate for inhibition of the growth of the intestinal protozoan parasite Cryptosporidium parvum. The concentration of pyrvinium
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