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dimethyl sulfoxide/maïs
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Hepatoprotection by dimethyl sulfoxide. II. Characterization of optimal dose and the latest time of administration for effective protection against chloroform and bromobenzene induced injury.
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Dimethyl sulfoxide (DMSO) has previously been shown to attenuate chloroform (CHCl3) and bromobenzene (BB) induced hepatotoxicity in the rat when a dose of 2.0 ml/kg is given 24 hr after the toxicants. However, the optimal dose of DMSO and the latest time at which DMSO can be administered and still
Effects of dimethyl sulfoxide (DMSO) on pulmonary fibrosis in rats and mice.
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Dimethyl sulfoxide (DMSO), a putative anti-inflammatory agent and free radical scavenger, was shown to protect against acute bleomycin-induced pulmonary fibrosis in the rat (Pepin and Langner, Biochem. Pharmacol., 34 (1985) 2386). We examined the effect of DMSO on bleomycin-induced pulmonary
Toxicity of polycyclic aromatic hydrocarbons. VI. Effects of 1-nitropyrene on serum enzyme levels in rats, and protection against it by beta-naphthoflavone and dimethyl sulfoxide.
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Male Sprague-Dawley rats were pretreated i.p. with corn oil or DMSO (1.5 ml/kg/day), or with beta-naphthoflavone (BNF, 40 mg/kg/day) in corn oil or DMSO for 3 days. 1-Nitropyrene (1-NP, 150 mg/kg) in DMSO was injected i.p. 24 hr after pretreatment. A significant increase in the levels of several
Intraperitoneal injections as a possible means of generating varied levels of methylmercury in the eggs of birds in field studies.
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The ideal study of the effects of methylmercury on the reproductive success of a species of bird would be one in which eggs contained mercury concentrations ranging from controls to very heavily contaminated, all at the same site. Such a study cannot be realized at a Hg-contaminated area or under
Effect of different administration paradigms on cholinesterase inhibition following repeated chlorpyrifos exposure in late preweanling rats.
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Chlorpyrifos (CPS) is widely used in agricultural settings and residue analysis has suggested that children in agricultural communities are at risk of exposure. This has resulted in a large amount of literature investigating the potential for CPS-induced developmental neurotoxic effects. Two
Sampling and analytical method development and hand wipe measurements of dermal exposures to polycyclic aromatic hydrocarbons.
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This article describes the laboratory assessment of a hand and surface wipe sampling method for polycyclic aromatic hydrocarbons (PAHs). The analytical method employed extraction of the wipe samples into dimethyl sulfoxide (DMSO) and high-performance liquid chromatography (HPLC) flourometric
Mammary carcinogenicity of diol epoxide metabolites of benzo[j]fluoranthene in female CD rats.
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The mammary carcinogenicity of two diol epoxide metabolites of the commonly occurring environmental carcinogen benzo[j]fluoranthene (BjF) was investigated by direct application to the tissue beneath the mammary glands of female CD rats. The compounds tested were
Citrate ester substitutes for di-2-ethylhexyl phthalate: In vivo reproductive and in vitro cytotoxicity assessments
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Di-2-ethylhexyl phthalate (DEHP) is frequently used as a plasticizer for wrapping films, in toys, and in medical devices. Previous studies demonstrated that DEHP in mouse reduced testicular and epididymis weights, suppressed levels of serum testosterone, luteinizing hormone, and follicle-stimulating
Chromosome doubling of haploids of common wheat with caffeine.
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Treatment of dividing plant cells with caffeine inhibits their cytokinesis, thereby inducing the formation of binucleate cells that contain polyploid nuclei. This study was undertaken to determine whether caffeine treatments would induce chromosome doubling and seed set in haploids of common wheat
Effects of dietary fat and aflatoxin B1 on microsomal monooxygenase activity.
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An acute experiment was conducted to determine the short-term effect of an LD50 dose of AFB1 on rats fed a diet containing either 30% corn oil (unsaturated) or 28% beef fat (saturated) for 3 weeks. The male weanling Wistar rats weighing 50-65 g were fed the respective dietary fats for 2 weeks and
Screening, purification, and characterization of an extracellular lipase from Aureobasidium pullulans isolated from stuffed buns steamers.
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An extracellular lipase from Aureobasidium pullulans was obtained and purified with a specific activity of 17.7 U/mg of protein using ultrafiltration and a DEAE-Sepharose Fast Flow column. Characterization of the lipase indicated that it is a novel finding from the species A. pullulans. The
Toxicological evaluation of 2-dodecylcyclobutanone, a unique radiolytic compound of palmitic acid.
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This study was conducted to evaluate the toxic effects and potency of 2-dodecylcyclobutanone (2-dDCB), a unique compound derived from palmitic acid via irradiation. In a series of assays of bacterial reverse-mutation, in vitro chromosomal aberration, and in vivo micronucleus, negative responses were
Cytoplasmic and wall isoperoxidases in growing maize roots.
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Cytoplasmic and wall-bound peroxidases (ionic and covalent) are extractable from maize roots (Zea mays L. cv. Orla 264). It is easier to extract ionic peroxidases when using divalent ions (Ca(+ +) and Mg(+ +))than monovalent ions (Na(+) and K(+)). The quantity of peroxidases extracted increases with
Megakaryocyte expansion and macrophage infiltration in bone marrow of rats subchronically treated with MNX, N-nitroso environmental degradation product of munitions compound RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine).
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Hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX), environmental degradation product of munitions hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), causes seizures in rats with acute oral exposure like parent RDX. Our previous studies have additionally reported hematotoxicity with acute MNX exposure
An assay to detect chemically induced DNA repair in rat spermatocytes.
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An in vivo/in vitro DNA repair assay has been developed to quantitate chemically induced unscheduled DNA synthesis (UDS) in rat spermatocytes utilizing autoradiography. Male Fischer-344 rats were treated by i.p. injection or gavage with a variety of genotoxic agents dissolved in dimethyl sulfoxide,
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