1000mg of (Hesperidin and Diosmin mixture) three times daily for 7 days 1000mg of (Hesperidin and Diosmin mixture) two times daily for 3 days

standard care therapy in quarantine hospitals

Coronavirus Infection

Hesperidin and Diosmin mixture

Hesperidin and Diosmin for Treatment of COVID-19

Randomized Double-blind Controlled Parallel Study of (Hesperidin and Diosmin Mixture) for Treatment of COVID-19 Newly Diagnosed Patients in Egypt

Prof. Dr. Kamal Mohammed Okasha

Professor

Tanta University

Randomized double-blind controlled Parallel study

Subjects who are SARS-CoV-2 PCR+ve and/or have diagnostic CXR or CT chest features of COVID -19

subjects admitted with COVID-19 like symptoms but are SARS-CoV-2 PCR-ve and have CXR or CT chest that show low probability of COVID-19 will form the control group

blood and urine samples for vascular phenotpying marker, immuno phenotyping markers and future biomarker studies

COVID

Hypertension

24 hour ambulatory blood pressure monitoring

ABPM

Rarefaction

NHS Greater Glasgow and Clyde

COVID-19 Blood Pressure Endothelium Interaction Study (OBELIX)

COVID-19 Blood Pressure Endothelium Interaction Study

Ambulatory Blood Pressure Monitoring systolic blood pressure

Ambulatory Blood Pressure Monitoring diastolic blood pressure

Day Ambulatory Blood Pressure Monitoring systolic blood pressure

Day Ambulatory Blood Pressure Monitoring diastolic blood pressure

Night Ambulatory Blood Pressure Monitoring systolic blood pressure

Night Ambulatory Blood Pressure Monitoring diastolic blood pressure

The fall in pressure, called the "dip", is defined as the difference between daytime mean systolic pressure and nighttime mean systolic pressure expressed as a percentage of the day value

he morning surge was defined as the difference between the mean systolic blood pressure during the 2 hours after waking and arising minus the mean systolic blood pressure during the hour that included the lowest blood pressure during sleep.

24 hour Ambulatory Blood Pressure Monitoring heart rate

Day Ambulatory Blood Pressure Monitoring heart rate

Night Ambulatory Blood Pressure Monitoring heart rate

University of Glasgow

The normal dose of ulinastatin for injection group(NUTIG):
Ulinastatin(Techpool inc,Guangdong,China) was administered to the group as a bolus of 100,000 U diluted in 100 mL of normal saline every 8 hour.A course of treatment consisted of 7 days after the patients were diagnosed as VAP.

The high dose of ulinastatin for injection group(HUTIG):
Ulinastatin(Techpool inc,Guangdong,China) was administered to the group as a bolus of 200,000 U diluted in 100 mL of normal saline every 8 hour.A course of treatment consisted of 7 days after the patients were diagnosed as VAP.

The compare group(CG):
The group was given 100 mL of normal saline every 8 hour.A course of treatment consisted of 7 days after the patients were diagnosed as VAP.

Ventilator-associated Bacterial Pneumonia

Mechanical Ventilation Complication

Ulinaststin for injection

placebo

Shanghai Minhang Central Hospital

The Effect of Ulinastatin on Bronchoalveolar Lavage Fluid of Inflammatory Factors in Patients With Ventilator-associated Pneumonia

The variety of tumor necrosis factor-α(TNF-α),interleukin-10(IL-10),interleukin-18(IL-18) and interferon-γ(INF-γ) in bronchoalveolar lavage fluid and blood serum are observed.

We will find whether the bacteria of multidrug-resistance can be isolated from the bronchoalveolar lavage fluid culture.
We will count the number of methicillin-resistant staphylococcus aureus(MRSA),extended-spectrum beta-lactamase(ESBLs) or vancomycin-resistant enterococcus(VRE) isolated from bronchoalveolar lavage fluid culture.

The adverse effects from using ulinastatin. Irritability,nausea,vomit,diarrhoea or the aspartate transaminaseere and alanine transaminase are more than one time the upper normal limit were regarded as the adverse effects.

Yu YueTian

Ruijin Hospital

RenJi Hospital

Shanghai Jiao Tong University School of Medicine

Placebo Group

Aminocaproic acid is an antifibrinolytic drug

Aminocaproic Acid Group

HOE 140 Group

Total

Sex: Female, Male

Region of Enrollment

Blood product transfusion during hospitalization that included packed red blood cells, plasma, platelets and cryoprecipitate.

Normal saline (placebo) was started in the operating room after induction of anesthesia and before heparinization, continued throughout the bypass period, and discontinued at the end of surgery.

Aminocaproic acid (an antifibrinolytic drug) was started in the operating room after induction of anesthesia and before heparinization, continued throughout the bypass period, and discontinued at the end of surgery. Aminocaproic acid was given as an intravenous bolus of 100 mg/kg over one-half hour followed by an infusion of 30 mg/kg/hr.

HOE 140 (a bradykinin B2 receptor antagonist) was started in the operating room after induction of anesthesia and before heparinization, continued throughout the bypass period, and discontinued at the end of surgery. HOE 140 was given as an intravenous bolus of 22 µg/kg over one-half hour followed by an infusion of 18 µg/kg/hr.

Allogenic Blood Product Transfusion Risk

Units of Packed Red Blood Cells Transfused

Units of Packed Red Blood Cells Transfused During Hospitalization

Units of Plasma Transfused During Hospitalization

Interleukin-6 was measured at baseline, post-bypass and on postoperative day 1 and 2.

Inflammatory Response as Measured by Interleukin-6

D-dimer concentrations were measured at baseline, 30min and 60min of bypass, post-bypass and postoperative day 1

disseminated intravascular coagulation/protease

Hesperidin and Diosmin for Treatment of COVID-19

COVID-19 Blood Pressure Endothelium Interaction Study (OBELIX)

The Effect of Ulinastatin on Bronchoalveolar Lavage Fluid of Inflammatory Factors in Patients With Ventilator-associated Pneumonia

Bradykinin Receptor Antagonism During Cardiopulmonary Bypass

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