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drimys/inflammation
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Polygodial, a sesquiterpene isolated from Drimys brasiliensis (Winteraceae), triggers glucocorticoid-like effects on pancreatic β-cells.
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Despite its common use, the synthetic glucocorticoid dexamethasone can cause several adverse effects, such as diabetes and insulin-related metabolic impairment. Thus, research on molecules that could provide the same anti-inflammatory response with milder side effects is constant. In this work the
Drimenol, isodrimeninol and polygodial isolated from Drimys winteri reduce monocyte adhesion to stimulated human endothelial cells
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The vascular endothelium is a continuous monolayer of endothelial cells that are in direct contact with the blood and its dysfunction is the starting process in the development of many pathological inflammatory disorders, such as atherosclerosis, which can result in death. The expression of adhesion
Isolation and identification of active compounds from Drimys winteri barks.
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The barks of Drimys winteri are used in folk medicine as a remedy to treat several diseases, including dolorous processes. Previous pre-clinical experiments carried out in our laboratories revealed that the hydroalcoholic extract of this plant showed anti-allergenic, anti-inflammatory and
Antifungal effects of drimane sesquiterpenoids isolated from Drimys winteri against Gaeumannomyces graminis var. tritici
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Gaeumannomyces graminis var. tritici (Ggt) is a soil-borne pathogen which causes 'take-all' disease affecting cereal roots. In wheat, Ggt is the most important biotic factor causing around 30-50% of yield losses. The chemical control of this fungal disease is difficult, due to Ggt is able to
Pharmacological and toxicological studies of Drimys angustifolia Miers. (Winteraceae).
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Drimys angustifolia Miers. (Winteraceae) is a Brazilian medicinal plant used as analgesic, antiulcer and anti-inflammatory without studies to assure its efficacy and safety Leaf and stem bark extracts were evaluated to determine the antiulcer, analgesic, antiinflammatory and antioxidant activities.
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