Midazolam PK assessment before and after steadystate ANS-6637

Opiod Use Disorder

Subjects will receive (1) midazolam 5 mg po single dose on Day 1 followed by (2) Drug free period on Day 2 followed by (3) ANS-6637 600 mg po daily (Days 3-7) to reach steady state followed by (4) ANS-6637 600 mg po single dose + midazolam 5mg po single dose on Day 8

ANS-6637

National Institutes of Health Clinical Center

The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers

The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers (SEARCH PK)

Pharmacokinetics of midazolam before and after steady state ANS-6637

Evaluate the safety and tolerability of administration of ANS-6637 alone or in combination with MDZ.

Describe the steady state pharmacokinetics of ANS- 6637 and GS-548351.

National Institutes of Health Clinical Center (CC)

National Institute of Allergy and Infectious Diseases (NIAID)

Nurse applies the daily-practice questionnaire called "Healthplan guide" to screen and identify people with dental diseases, among those in vulnerable situation, and to sensitize them about the importance of oral hygiene and how to improve it.
After that, the nurse has to state if, from her/his point of view the patient needs dental care or not. Whatever the answer, the nurse makes an appointment to a dental practice, in the 30 following days, and gives it to the patient with a free bus ticket. Randomization is done at that time.
The dentist, blinded of the patient's group, makes a dental exam and says if the patient needs dental care or not.
If care are indicated, they will be organized but outside this trial.

After application of the "Healthplan guide", nurse statement of the need of dental care or not, making of an appointment to the dental practice and gift of a free bus ticket, if the patient is randomized in the experimental group, the nurse completes the evaluation with a mouth inspection in order to count missing, coloured, injured teeth, and evaluate dental plaque, halitosis, inflammatory gums, mucosal injuries, low masticatory surface. At the end of this exam, the nurse has to state again if, from her/his point of view the patient needs dental care or not.
The dentist, blinded of the patient's group, makes a dental exam and says if the patient needs dental care or not.
If care are indicated, they will be organised but outside this trial.

Homeless and Low Incomes People, Refugees

Mouth inspection done by a nurse, in order to count missing, coloured, injured teeth, and evaluate dental plaque, halitosis, inflammatory gums, mucosal injuries, low masticatory surface.

Oral and dental evaluation

ADOMA

Centre d'hébergement et de réinsertion sociale Saint-François

L'Herminette

L'Intervalle

La Halte

Ma Bohème

CH Annecy Genevois

Oral Evaluation by the Nurses From the Office of Access to Healthcare ("PASS") for Vulnerable People - PASSDENT Study

Oral Evaluation by the Nurses From the Office of Access to Healthcare ("PASS") for Vulnerable People as a Vector for the Detection of Oral Diseases to Improve Access to the Appropriate Healthcare Branch - PASSDENT Study

Rate of people who go to the dental practice after an appointment booked by the nurse of the PASS structure

Oral evaluation and oral hygien index done by dentists with only one evaluation form

Comparison of nurse and dentist evaluations concerning the need of dental care

Agreement between nurse and dentist concerning number and location of missing, coloured, injured teeth (according to the World Dental Federation two-digit notation), dental plaque, halitosis, inflammatory gums, mucosal injuries, low masticatory surface.

Centre Hospitalier Annecy Genevois

Impact of an oral evaluation realized by a nurse combined with a questionnaire (the healthplan guide)

Group A: Patients with known BAV who are scheduled to have a cardiac MRI.

Group B: Patients with known BAV who have already had an MRI within the past year

All patients who do undergo valve replacement or aortic graft surgery within the 24 month follow up period, will have their valve tissue samples analyzed for podocan levels. These tissues are removed as a routine part of the surgery and sent to the clinical laboratory at Bassett. The Bassett Clinical Lab will prepare additional paraffin blocks and slides of the tissue for the research study. Specifically, aortic aneurysm and aortic root tissue will be analyzed. The relationship between cell density (mm2) and Podocan, in addition to the six Wnt molecule levels, will be analyzed.

endocarditis/− nicotine

The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers

Oral Evaluation by the Nurses From the Office of Access to Healthcare ("PASS") for Vulnerable People - PASSDENT Study

Podocan and Wnt Pathway in the Development of Aortopathy in Bicuspid Valve Disease

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