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Page 1 de 33 résultats
Methods for treatment of kallikrein-related disorders
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BACKGROUND OF THE INVENTION
The invention relates to methods for treating plasma kallikrein-related disorders, such as diseases or conditions associated with increased vascular permeability or astrocyte activation. Such diseases include diabetic retinopathy, macular edema, intracerebral hemorrhage,
Prodrug salts
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TECHNICAL FIELD
Provided are novel prodrug salts of selective aquaporin inhibitors, e.g., of aquaporin-4 and/or aquaporin-2, of Formula I as described below, their use as pharmaceuticals and pharmaceutical compositions comprising them, and novel intermediates used in and novel processes for their
Prodrug salts
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TECHNICAL FIELD
Provided are novel prodrug salts of selective aquaporin inhibitors, e.g., of aquaporin-4 and/or aquaporin-2, of Formula I as described below, their use as pharmaceuticals and pharmaceutical compositions comprising them, and novel intermediates used in and novel processes for their
Method of treating migraine headache without aura
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TECHNICAL FIELD OF THE INVENTION
The present invention relates to methods and compositions for treating selected conditions of the central and peripheral nervous systems employing non-synaptic mechanisms. More specifically, one aspect of the present invention relates to methods and compositions for
Methods and compositions for treating conditions of the central and peripheral nervous systems using non-synaptic mechanisms
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TECHNICAL FIELD OF THE INVENTION
The present invention relates to methods and compositions for treating selected conditions of the central and peripheral nervous systems employing non-synaptic mechanisms. More specifically, one aspect of the present invention relates to methods and materials for
Triaza-cyclopenta[cd]indene derivatives
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This Application is a 371 of PCT/JP2005/000323, filed Jan. 6, 2005; the disclosure of which is incorporated herein by reference.
DETAILED DESCRIPTION OF THE INVENTION
1. Technical Field
The present invention relates to a therapeutic agent for diseases in which corticotropin releasing factor (CRF) is
Pyrrolopyrimidine and pyrrolotriazine derivatives
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This Application is a 371 of PCT/JP2005/000319, filed Jan. 6, 2005.
DETAILED DESCRIPTION OF THE INVENTION
1. Technical Field
The present invention relates to a therapeutic agent for diseases in which corticotropin releasing factor (CRF) is considered to be involved, such as depression, anxiety,
Substituted thieno[3,2-d]pyrimidines as CRF receptor antagonists
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This Application is a 371 of PCT/JP2005/000318, filed Jan. 6, 2005; the disclosure of which is incorporated herein by reference.
DETAILED DESCRIPTION OF THE INVENTION
1. Technical Field
The present invention relates to a therapeutic agent for diseases in which corticotropin releasing factor (CRF) is
Pyrrolopyridine derivatives substituted with cyclic amino group
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DETAILED DESCRIPTION OF THE INVENTION
1. Technical Field
The present invention relates to a therapeutic agent for diseases in which corticotropin releasing factor (CRF) is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating
Pyrrolo[2,3-d]pyrimidine derivatives substituted with a cyclic amino group
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DETAILED DESCRIPTION OF THE INVENTION
1. Technical Field
The present invention relates to a therapeutic agent for diseases in which corticotropin releasing factor (CRF) is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating
Prodrug amino acid derivative
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TECHNICAL FIELD
The present invention relates to prodrugs of (1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-alkoxybicyclo[3.1.0]hexane-2,6-dicarb- oxylic acid derivatives and (1S,2R,3R,5R,6S)-2-amino-3-alkoxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives useful as drugs. More specifically, the present
Prodrug of amino acid derivative
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CROSS-REFERENCE TO RELATED PATENT APPLICATIONS
This application is a National Stage Entry of International Application No. PCT/JP2017/016125, filed Apr. 18, 2017, which claims priority from Japanese Patent Application No. 2016-083147, filed Apr. 18, 2016. The entire contents of the above-referenced
Bumetanide analogs, compositions and methods of use
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FIELD OF THE INVENTION
The present invention relates to bumetanide, furosemide, piretanide, azosemide, and torsemide analogs, including derivatives, positional isomers, and prodrugs thereof, compositions comprising the same and methods of making and using the same. The present invention also relates
.beta.- and .gamma.-diketones and .gamma.-hydroxyketones as WNT/ .beta.-catenin signaling pathway activators
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to activators of one or more proteins in the Wnt pathway, including activators of one or more Wnt proteins, and compositions comprising the same. More particularly, it concerns the use of a .beta.-diketone, .gamma.-diketone
.beta.- and .gamma.-diketones and .gamma.-hydroxyketones as WNT/ .beta.-catenin signaling pathway activators
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to activators of one or more proteins in the Wnt pathway, including activators of one or more Wnt proteins, and compositions comprising the same. More particularly, it concerns the use of a .beta.-diketone, .gamma.-diketone
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