Patients will abnormal distal acid esophageal exposure will receive PPI twice daily for 8 weeks .

Patients with positive symptom index for chest pain will receive citalopram 20 mg once daily and PPI once daily for 8 weeks.

Patients with a negative symptom index for chest pain will receive citalopram 20mg once daily for 8 weeks

Chest Pain Rule Out Myocardial Infarction

Citalopram

Evangelismos Hospital

PPI's and SSRI's Therapy for the Management of NCCP

Proton Pump Inhibitor (PPI's) and Selective Serotonin Reuptake Inhibitor Therapy (SSRI's) for the Management of Non Cardiac Chest Pain (NCCP)

Nikos Viazis

Director

4-weeks buspirone administration (20mg) in patients with SSc and esophageal involvement

22 out of 30 participants (19 female) completed the study.

Buspirone

Sex: Female, Male

Region of Enrollment

Participants received buspirone 20 mg/day for 4 weeks

Changes From Baseline in Manometric Parameters: i) Amplitude of Contractions at the Distal Part of the Esophagus and ii) Resting and Residual (Lower Esophageal Pressure) LES Pressure and IRP (Integrated Relaxation Pressure) at Week 4

4-weeks buspirone administration (20mg) in patients with SSc and esophageal involvement
buspirone: buspirone 10 mg X2 for 4 weeks

Changes From Baseline in Manometric Parameters: Duration of Contractions at the Distal Part of the Esophagus at Week 4

Changes From Baseline in Manometric Parameters: Velocity of Contractions at the Distal Part of the Esophagus at Week 4

Severity of esophageal symptoms (dysphagia, heartburn, regurgitation and chest pain) was measured on a 100-point visual analogue scale (VAS) ranging from 0 (absent) to 100 (very severe). Even minor decrease in the VAS score for each symptom at week 4 considered as improvement.

Changes in the Severity of Esophageal Symptoms at Week 4

Overall Study

Dr. George P. Karamanolis

Participants received bouspirone 20 mg/day for 4 weeks

esophageal motility disorders/sérotonine

PPI's and SSRI's Therapy for the Management of NCCP

Long Term Effect of Buspirone on Esophageal Function and Esophageal Symptoms in Patients With Systematic Sclerosis (SSc)

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