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Assessing Toxicity of Waterpipe Tobacco Smoking

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Globally, 1 in 3 adults or 1.2 billion people smoke. The World Health Organization (WHO) estimated that tobacco is responsible for the death of 1 in 10 adults worldwide, about 6 million premature deaths each year. In the United States (U.S.), cigarette smoking is responsible for more than 480,000

NCI UNC Project ESCC

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Background: Esophageal cancer causes an estimated 400,000 deaths per year and ranks as the sixth leading cause of cancer death worldwide, just after breast cancer. Esophageal squamous cell carcinoma (ESCC) accounts for 89% of all esophageal cancer cases worldwide and many of the cases originate in

Labeled Nornicotine in Smokeless Tobacco

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The tobacco alkaloid nornicotine is a precursor to N'-nitrosonornicotine (NNN), a potent tobacco-specific carcinogen. NNN is believed to play an important role in the induction of esophageal and oral cavity cancers in tobacco users. Nornicotine contributes to NNN exposure in tobacco users in two

Quit and Fit: A Tobacco Cessation and Energy Balance Pilot for African Americans

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1. * Purpose of project (one or two sentences): The feasibility phase of the proposed study is comprised of a two-arm randomized pilot trial to evaluate the feasibility, satisfaction, and preliminary efficacy of 'Quit & Fit'. Women (N=40) will receive 12 weekly smoking cessation telephone counseling

A Pilot for a Case-Control Study of Esophageal Squamous Cell Carcinoma in Western Kenya

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This pilot study will assess the feasibility of completing the first formal case-control study to examine etiologic factors for esophageal squamous cell carcinoma (ESCC) in Kenya and will be conducted in Western Kenya, a high-risk area for ESCC. Esophageal cancer causes over 380,000 deaths per year

The Study of Barrett's Esophagus: What Are the Factors of Progression

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Barrett's esophagus (BE) is defined as a change in the esophageal mucosa from normal squamous epithelium to columnar epithelium with intestinal metaplasia (1). There is compelling evidence that BE is a precursor lesion for adenocarcinoma of the esophagus (2). There is also evidence that the

Is Screening for Esophageal Pathology in Asymptomatic Patients Post-Treatment for Head and Neck Cancer Beneficial?

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There are certain factors (i.e. alcohol, tobacco, decreased saliva production from radiation) that predispose patients with a history of head and neck cancer to have esophageal disease. Often, in the initial stages of the disease, patients do not have symptoms. However, the early detection of

Esophageal Cancer in Northeastern Iran

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Esophageal cancer is the sixth most common cause of cancer death worldwide, killing over 380,000 people each year. Over 80% of esophageal cancers occur in developing countries, where the great majority of cases are squamous cell carcinomas. Esophageal cancer is characterized by striking geographic

Stomach and Esophageal Cancers in Northern Iran

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This case-control study (the first phase of the GEMINI project) is primarily focused on exploring the etiology (etiologies) of squamous cell carcinoma of the esophagus in northern Iran. Esophageal and gastric cancers, together, are responsible for more than 1,000,000 annual deaths in the world. In

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