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gangrene/carbohydrate
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[On the prognosis of gangrene in diabetes mellitus with special reference to familial and genetic diabetes and carbohydrate metabolism management before the manifestation of gangrene].
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[Compensation of carbohydrate metabolism in patients with moist gangrene of the extremities and diabetes mellitus].
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Fulminant group A streptococcal infection without gangrene in the extremities: Analysis of five autopsy cases.
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Five autopsy cases of fulminant group A streptococcal infection without gangrene in the extremities are presented. Clinical course of the fulminant illness was short (2-4 days). One pathological autopsy case was aged (86-years-old), and hemorrhagic cystitis was observed. The other four forensic
[Treatment of gangrene of the lower limbs in diabetes mellitus].
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In 54 patients with diabetic gangrenes of lower extremities the complex treatment was used aimed at changing moist gangrene into dry one, decreased intoxication, normalization of carbohydrate metabolism and improvement of tissue trophicity. In 18 patients the complex of curative measures included
1H, 15N and 13C backbone and side-chain resonance assignments of a family 32 carbohydrate-binding module from the Clostridium perfringens NagH.
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The Gram-positive anaerobe Clostridium perfringens is an opportunistic bacterial pathogen that secretes a battery of enzymes involved in glycan degradation. These glycoside hydrolases are thought to be involved in turnover of mucosal layer glycans, and in the spread of major toxins commonly
Arterial calcification in diabetics.
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Calcification of the media of the arteries of the lower limbs, giving a linear type of calcification roentgenologically is typical for diabetic arteriosclerosis. Spotty calcification of the arteries of the lower extremity, which histologically is found in the intima, is also seen a little more often
[Diagnosis and treatment of diabetic angiopathy of the lower extremities].
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Experience in the treatment of 77 patients with diabetic angiopathy of the lower limbs is discussed. Various pyonecrotic complications developed in 44% of cases. Laboratory and instrumental diagnostic methods included general clinical, biochemical, and coagulation tests, angiography, dopplerography,
Clostridium perfringens alpha-toxin recognizes the GM1a-TrkA complex.
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Clostridium perfringens alpha-toxin is the major virulence factor in the pathogenesis of gas gangrene. Alpha-toxin is a 43-kDa protein with two structural domains; the N-domain contains the catalytic site and coordinates the divalent metal ions, and the C-domain is a membrane-binding site. The role
Antibiotics for skin and soft tissues infections in type 2 diabetes mellitus.
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BACKGROUND
Type 2 diabetes mellitus is a chronic pathology characterized by high prevalence, high morbidity and mortality. According to the data of the Ministry of Health of Volgograd region the number of patients with type 2 diabetes was 68,227 people on 01.01.2014. Medical and social significance
[Differentiation of pathogenic clostridia from material collected in the field and of reference strains by means of biostatistical analysis of the quantitatively recorded metabolic fatty acid patterns of the agents (author's transl)].
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34 reference and 9 exotic field strains of clostridia were analyzed by means of gas liquid chromatography (GLC) on their patterns of metabolic short chain fatty acids. To increase the number of criteria for the differentiation specimens were grown on pepton yeast medium with addition of 13 different
Association of differing dietary, metabolic, and clinical risk factors with macrovascular complications of diabetes: a prevalence study of 503 Mexican type II diabetic subjects. I.
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Macrovascular and microvascular complications of diabetes may be associated with different environmental factors. To investigate this further, a prevalence study of 503 Mexican type II diabetic subjects was carried out while their patterns of nutrition were constrained by government food subsidies.
Multiple effects on Clostridium perfringens binding, uptake and trafficking to lysosomes by inhibitors of macrophage phagocytosis receptors.
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Clostridium perfringens is a Gram-positive, anaerobic bacterium that is the most common cause of gas gangrene (clostridial myonecrosis) in humans. C. perfringens produces a variety of extracellular toxins that are thought to be the major virulence factors of the organism. However, C. perfringens has
[The alpha-glycerolphosphate dehydrogenase and adenosinetriphosphatase activity of the peripheral blood lymphocytes in diabetics (a cytochemical determination)].
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Decrease in activity of alpha-GPDG and ATP-ase observed in peripheral lymphocytes of patients with diabetes mellitus correlated well severity of the disease. The lowest indices of enzymatic activity were registered in patients with grave diabetes complicated by angiopathies, foot gangrene, and
[Tactics of surgical treatment of suppurative-necrotic lesions of the foot and leg in patients with diabetes mellitus].
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Policy of surgical treatment of 200 patients with pyonecrotic lesions of the lower limbs and diabetes mellitus are analysed. The management of such patients should provide timely adequate surgical treatment of the focus of affection, correction of carbohydrate metabolism with increased doses of
[Diabetic osteopathy (an analysis of 37 cases)].
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This paper reported the result of clinicoradiologic analysis of 37 patients with diabetic osteopathy. The site of predilection was the bony ends of the extremities, especially the foot (91.9%). The main clinical manifestation was the presence of a non-healing chronic ulcer, whereas diabetic gangrene
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