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Page 1 de 86 résultats
Prevention of mammary tumors by treatment with cardiac glycosides
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TABLE OF CONTENTS
1. Introduction
2. Background of the Invention
2.1. Chemical Nature and Properties of the Cardiac Glycosides
2.2. Pharmacokinetics of the Cardiac Glycosides
2.3. Cardiac Glycosides and Cancer
2.4. Cancer Prevention
3. Summary of the Invention
4. Detailed Description of the
Method of treating tumors with pharmaceutical composition containing anthracycline glycosides
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The present invention relates to stable, rapidly soluble, lyophilised injectable preparations comprising an anthracycline glycoside, or a pharmacutically acceptable salt thereof, as the active drug substance, and to the use of said preparations in the treatment of tumours.
The lyophilised
Method of treating tumors with a pharmaceutical composition containing anthracycline glycosides
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The present invention relates to stable, rapidly soluble, lyophilised injectable preparations comprising an anthracycline glycoside, or a pharmaceutically acceptable salt thereof, as the active drug substance, and to the use of said preparations in the treatment of tumours.
The lyophilised
Method of determining the probability of a therapeutic response in cancer chemotherapy with cardiac glycoside
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FIELD OF THE INVENTION
The present invention concerns a method of determining the prognosis in cancer chemotherapy with a cardiac glycoside. In particular, the invention concerns a method for determining the probability of whether or not an in vitro or in vivo cell disease or disorder having an
Method of determining the probability of a therapeutic response in cancer chemotherapy with cardiac glycoside
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FIELD OF THE INVENTION
The present invention concerns a method of determining the prognosis in cancer chemotherapy with a cardiac glycoside. In particular, the invention concerns a method for determining the probability of whether or not an in vitro or in vivo cell disease or disorder having an
Gem-difluorinated C-glycoside compounds as anti-cancer agents
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BACKGROUND
(a) Field
The subject matter disclosed generally relates to novel chemical compounds and methods. More particularly, the invention provides novel derivatives of podophyllotoxin with a gem-difluoronated compound, having improved conformational and chemical stability, and having improved
Cardiac glycoside analogs in combination with emodin for cancer therapy
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to cancer therapeutics. More specifically it concerns the use of cardiac glycosides such as Digoxin and Quabain in combination with Emodin and its analogs for the treatment of cancer.
2. Description of the
Process for preparation of glycosides of tumor-associated carbohydrate antigens
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to the preparation of novel glycosides of tumor-associated carbohydrate haptens.
2. Description of the Background Art
Tumor Associated Carbohydrate Antigenic Determinants. Numerous antigens of clinical significance
C-glycoside analogues of N-(4-hydroxyphenyl)retinamide-O-glucuronide
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BACKGROUND OF THE INVENTION
Breast cancer kills thousands of women annually. While surgical intervention has saved the lives of many women, radical and partial mastectomies often prove physically and emotionally debilitating. Indeed, surgery, even when combined with chemotherapy, may still expose
C-glycoside analogues of N-(4-hydroxyphenyl)retinamide-O-glucuronide
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BACKGROUND OF THE INVENTION
Breast cancer kills thousands of women annually. While surgical intervention has saved the lives of many women, radical and partial mastectomies often prove physically and emotionally debilitating. Indeed, surgery, even when combined with chemotherapy, may still expose
Steroidal C-glycosides
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FIELD OF THE INVENTION
The invention relates to the field of medicinal chemistry, and more specifically to steroidal glycosides wherein the glycoside is linked directly, or indirectly to a desired steroidal compound via a carbon linkage, to formulations containing such, and their use in treating
Method of treatment employing cardiac glycoside
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FIELD OF THE INVENTION
The present invention concerns a method of determining the prognosis in cancer chemotherapy with a cardiac glycoside. In particular, the invention concerns a method for determining the probability of whether or not an in vitro or in vivo cell disease or disorder having an
Pharmaceutical compositions containing anthracycline glycosides
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The present invention relates to stable, rapidly soluble, lyophilised injectable preparations comprising an anthracycline glycoside, or a pharmaceutically acceptable salt thereof, as the active drug substance, and to the use of said preparations in the treatment of tumours.
The lyophilised
Pharmaceutical compositions containing anthracycline glycosides
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The present invention relates to stable, rapidly soluble, lyophilised injectable preparations comprising an anthracycline glycoside, or a pharmaceutically acceptable salt thereof, as the active drug substance, and to the use of said preparations in the treatment of tumours.
The lyophilised
Neoplasmic compounds: sugar esters and glycosides
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BACKGROUND AND SUMMARY OF INVENTION
The compounds of the invention and the pharmaceutically acceptable acid-addition salts thereto relate to and are useful as active ingredients for pharmaceuticals, especially for topical administration. Similar compounds have been used in the treatment of acne and
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