3 résultats
BACKGROUND OF THE INVENTION
Cyclic GMP (cGMP) is an important intracellular messenger which triggers a multitude of different effects via the modulation of cGMP-dependent protein kinases, phosphodiesterases and ion channels. Examples are the relaxation of smooth muscles, the inhibition of
The invention relates to novel 1-(p-thienylbenzyl)imidazoles of formula (I), ##STR2##
which are potent agonists of angiotensin (1-7) receptors and, because of the production land release of the vasorelaxant, antithrombotic, and cardio-protective messengers cyclic 3',5'-guanosine monophosphate (cGMP)
The invention relates to novel 1-(p-thienylbenzyl)imidazoles of formula (I), ##STR2##
which are potent agonists of angiotensin (1-7) receptors and, because of the production hand release of the vasorelaxant, antithrombotic, and cardio-protective messengers cyclic 3',5'-guanosine monophosphate (cGMP)