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hemoglobinopathies/albumine
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Glycated albumin and diabetes mellitus.
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BACKGROUND
Diabetes is a growing worldwide problem that is strongly associated with atherosclerosis. Screening and intervention for diabetes in the earliest stages are advocated for the prevention of diabetic complications and cardiovascular disease.
METHODS
This review gives a background of and
Gold nanoparticle-based tool to study protein conformational variants: implications in hemoglobinopathy.
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The size of gold nanoparticles is shown here to gradually decrease if it is allowed to grow on a protein template, and the protein is subjected to unfolding by a nonionic denaturant. The correlation between size of the gold nanoparticle formed and the plasmon frequency observed remains linear,
Cardiorenal risk prevalence in sickle cell hemoglobinopathy.
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BACKGROUND
The spectrum of kidney functional and structural alterations in sickle cell hemoglobinopathy (SCH) is broad. Also, morbidity and mortality from end organ dysfunction, especially cardiorenal dysfunction, are substantial. Consequently, screening an SCH population prospectively for surrogate
Glycated albumin.
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Glycated hemoglobin (HbA1c) is the reference test for long-term glucose monitoring. However, HbA1c is not recommended in several situations such as hemoglobinopathies, pregnancy or chronic kidney disease. The quantification of serum glycated albumin (GA) can serve as an
Glycated albumin: a potential biomarker in diabetes.
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Diabetes mellitus (DM) is a chronic and metabolic disease that presents a high global incidence. Glycated hemoglobin (A1C) is the reference test for long-term glucose monitoring, and it exhibits an association with diabetic chronic complications. However, A1C is not recommended in clinical
Glomerular involvement in adults with sickle cell hemoglobinopathies: Prevalence and clinical correlates of progressive renal failure.
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Patients with sickle cell anemia (SCA) may develop a glomerulopathy with proteinuria and progressive renal insufficiency, leading to ESRD. Albuminuria is a sensitive marker of glomerular damage in this population and precedes the development of renal insufficiency. For determination of the
Effects of centrifugation on transmembrane water loss from normal and pathologic erythrocytes.
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Plasma 125I-albumin was used as a marker of extracellular dilution in order to study the effect of high-speed centrifugation on transmembrane water distribution in several types of human red cells, including normal (AA), hemoglobin variants (beta A, AS, SC, beta S, and SS), and those from patients
The Sickle Effect: The Silent Titan Affecting Glycated Hemoglobin Reliability
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Hemoglobin A1c (HbA1c) is a popular invaluable tool in the diagnosis of Type 2 diabetes for red blood cells (RBCs) with a lifespan of 120 days; however, many factors, including hemoglobinopathies, affect its accuracy. Sickle cell trait, primarily a benign medical condition, is a point mutation in
Risk of zinc, iodine and other micronutrient deficiencies among school children in North East Thailand.
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BACKGROUND
Micronutrient deficiencies during childhood can contribute to impairments in growth, immune competence, and mental and physical development, and the coexistence of several such deficiencies can adversely affect the efficacy of single micronutrient interventions.
OBJECTIVE
To assess the
Hemoglobin Himeji and inconsistent hemoglobin A1c values: a case report.
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BACKGROUND
Hemoglobin A1c is used to evaluate the glycemic control in patients with diabetes and is a risk marker for chronic complications of diabetes. Hemoglobin variants are reported to falsely lower or increase hemoglobin A1c test results. We present a case report of a patient with diabetes with
The involvement of low-density lipoprotein in hemin transport potentiates peroxidative damage.
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Hemin binds to isolated low-density lipoprotein (LDL) and thereby triggers LDL oxidation. In this study we investigated whether hemin can get together with LDL under physiological conditions. The relative affinity of three blood components to free hemin was as follows: RBCM < LDL < albumin. At
[Study of the protein profile of the Adélé tribe of Togo].
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Plasma proteins provide precise information about the physiological status of an individual. In this study, we compared the plasma protein profiles of 168 individuals from the Adélé ethnic group, from an isolated rural area of Togo, with those of 159 individuals from an urban population from the
Early Predictors of Renal Dysfunction in Pediatric Patients with Sickle Cell Disease.
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Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by abnormal hemoglobin production which leads to hemolytic anemia and intermittent occlusion of small blood vessels, which further leads to tissue ischemia, chronic organ damage, and organ dysfunction including urinary system.
Zinc status of children with sickle cell disease: relationship to poor growth.
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We examined the zinc status of 80 children with sickle cell disease (SCD) and 44 disease-free sibling controls aged 3 to 18 years. For both patients and controls, variations in serum zinc by age, type of hemoglobinopathy, and growth status were measured. The mean serum zinc concentration of patients
Origin and utility of the reverse dot-blot.
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Reverse allele specific oligonucleotide assays provide a robust method for the molecular characterization of high-mutation spectrum disorders. Commercial test have been developed for human leukocyte antigens class I and class II regions of human chromosome 6, the cystic fibrosis transmembrane
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