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12 résultats
The Investigation of the Causes of Hepatic Dysfunction in the Postoperative Period During Open-heart Surgeries
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There are a series of pathophysiological changes in patients undergoing open-heart surgeries with cardiopulmonary bypass (CPB) that causes liver hypoperfusion, centrilobular sinusoid ischemia, and subsequent reperfusion injuries, hemolysis, or systemic inflammatory response. These events may
Collection of Data of Ceftobiprole Treated Patients: Comparison of Patients With and Without Certain Diseases
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Rationale and background:
Ceftobiprole is a beta-lactam antibiotic with bactericidal activity against a broad spectrum of Gram-positive and Gram-negative bacteria, that was developed to treat patients with pneumonia both in a hospital or community setting. Clinical trials were conducted in adult
Recovery and Lifespan of Red Blood Cells From Pathogen-reduced, Stored Blood Units
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Each subject will receive one infusion of autologous, radiolabeled and BioRBC labeled INTERCEPT RBCs (Test RBCs) and one infusion of autologous BioRBC labeled untreated RBCs (Control RBCs) concomitantly. Each infusion will be approximately 20 mL, i.e., 10 mL of 51-chromium labeled RBC, and 10 mL of
A Study to Systematically Assess the Efficacy and Safety of Intravenous Albumin Infusions in Severe POTS
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Purpose
To assess the efficacy and safety of intravenous 5% albumin infusions in severe Postural Orthostatic Tachycardia Syndrome (POTS).
Hypothesis
Periodic albumin infusions will be effective in treating patients with severe Postural Orthostatic Tachycardia Syndrome (POTS)
Justification
POTS is
Biomarker for Gilbert Disease (BioGilbert)
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Gilbert syndrome is a mild genetic liver disorder in which the body cannot properly process bilirubin, a yellowish waste product that is formed when old or worn out red blood cells are broken down (hemolysis). It is inherited as an autosomal recessive trait.
Individuals with Gilbert syndrome have
Bilirubin Binding Capacity to Assess Bilirubin Load in Preterm Infants
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The investigator intends to first collect simultaneous and comprehensive "acute phase" measurements of TB, BBC, ETCOc, and COHbc in MPT infants. The investigator will then seek to understand precisely the relationship between GA, TB, BBC, ETCOc, and COHbc levels and the domains of BIND. Third, The
Clinical Trial to Evaluate the Use of an Adsorption Membrane (oXiris®) During Cardiopulmonary Bypass Surgery
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The oXiris® set connection to CPB
- The PrismafleX eXeed™ II (Baxter) system control unit will be used to deliver CRRT and thus connected to the CPB circuit through the oXiris® set lines.
- Priming. For oXiris® set priming use 2 L of normal saline according to the software instructions.
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Single-center Prospective Evaluation of Sickle Cell Patient Care in the CHU Brugmann Emergency Department
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The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders
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The research protocol extends for up to 12 months, during which the participant will attend 3 clinic visits at Shaare Zedek Medical Centre; one at study enrollment, one at 6 months and one at 12 months.
All patients identified will have their medical records reviewed for previous clinical,
Cultured Red Blood Cells : Life Span in Vivo Study
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1. GENERALITIES
1.1 Clinical grade production of cRBC In this study the cRBC is both the active principle and the final product subjected to radioactive chromium labeling.
The quantity of 5x109 cRBC to be reinjected is determined by the necessity to have a quantity of radioactivity lying between
Study of Albumin to Reduce Inflammation Following Surgery
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The host response to infection and other forms of tissue injury has been termed the systemic inflammatory response syndrome (SIRS). SIRS is seen in association with a wide variety of non-infective insults, including major trauma and surgical procedures, including those necessitating cardiopulmonary
Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension
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Sickle cell anemia is an autosomal recessive disorder and the most common genetic disease affecting African-Americans. Approximately 0.15% of African-Americans are homozygous for sickle cell disease, and 8% have sickle cell trait. Acute pain crisis, acute chest syndrome (ACS), and secondary
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