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Proline at position 14 of alamethicin is essential for hemolytic activity, catecholamine secretion from chromaffin cells and enhanced metabolic activity in endothelial cells.
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Alamethicin is known to lyse different biological cells and to induce voltage dependent ion channels in lipid bilayers. A set of analogs with proline shifted from position 14 in the native peptide towards the N- and C-terminus was used to investigate the role of proline in: (i) alamethicin induced
Biomedical research of novel biodegradable copoly(amino acid)s based on 6-aminocaproic acid and L-proline.
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The biomedical properties of novel biodegradable copoly(amino acid)s based on 6-aminocaproic acid and L-proline were analyzed in this article. The cytotoxicity of the copolymer films was tested in vitro using human embryonic kidney (HEK) 293 cells. The cell proliferation, cell cycle, cell apoptosis,
Proline transport and metabolism in Rickettsia prowazekii.
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Purified Rickettsia prowazekii cells were able to transport L-proline. The influx of this amino acid had a Kt of 14 microM and a Vmax of about 64 pmol/min per mg of protein. Proline could not be transported by heat-killed or metabolically poisoned rickettsiae or at 0 degrees C. The uptake of proline
Proline induced hemolytic anemia in fascioliasis.
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A secondary anemia is characteristic of infections with the liver fluke, Fasciola hepatica, and previous studies had suggested that proline released by the worm might be involved in producing this condition. In the current study the effect of fascioliasis on erythropoiesis was compared to the
A Thioether-Stabilized d-Proline-l-Proline-Induced β-Hairpin Peptide of Defensin Segment Increases Its Anti-Candida albicans Ability.
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We report a β-hairpin dual stabilizing strategy: a d-proline-l-proline (d-Pro-l-Pro) dipeptide as the nucleating turn, and a thioether tether as a side-chain linkage at a precisely designed position to stabilize the β-hairpin. This method was used to modify the C-terminal β-hairpin moiety of the
Transitory postnatal hemolysis of calf red cells by amino acids.
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Among the amino acids which can be solubilized to give a concentration of 300 mm at near physiological pH, histidine and proline caused a complete hemolysis of newborn calf but not of adult cow red cells within 20 to 30 minutes at 38 degrees C. While hydroxyproline, valine, and serine resulted in a
Natural cryoprotectants combinations of l-proline and trehalose for red blood cells cryopreservation.
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Cryopreservation of red blood cells (RBCs) holds great potential benefits for supplying transfusion timely in emergencies. Currently, glycerol is the main cryoprotectant permitted in clinical therapy for RBCs cryopreservation, but its broad application is limited by the toxicity and complex
Oxidative stress parameters and anti-apoptotic response to hydroxyl radicals in fish erythrocytes: protective effects of glutamine, alanine, citrulline and proline.
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The present study explored the protective effects of glutamine (Gln), alanine (Ala), citrulline (Cit) and proline (Pro) on hydroxyl radical (·OH)-induced apoptosis in isolated carp erythrocytes. Hydroxyl radicals were generated by ferrous ion (Fe(2+))-mediated decomposition of hydrogen peroxide
Effects on haemolytic activity of single proline substitutions in the Bordetella pertussis CyaA pore-forming fragment.
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The recombinant Bordetella pertussis CyaA pore-forming (CyaA-PF) fragment was previously shown to be expressed separately in Escherichia coli as a soluble precursor that can be in vivo palmitoylated to exert haemolytic activity. In this study, PCR-based mutagenesis was employed to investigate the
A novel mutation in the complement regulator clusterin in recurrent hemolytic uremic syndrome.
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A novel heterozygous mutation in the clusterin gene, nucleotide position A1298C (glutamine>proline Q433P), was detected in exon 7 of a child with recurrent hemolytic uremic syndrome (HUS). The same mutation was found in the child's two siblings and mother but not in 120 controls. In addition, a
Genomic and Proteomic Analysis of Escherichia coli After Spaceflight Reveals Changes Involving Metabolic Pathways.
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OBJECTIVE
The space environment could have impacts on a variety of characteristics of microorganism such as cell metabolism, drug resistance, and virulence. However, relevant mechanisms need to be clarified. In the present study, the effect of a space environment on Escherichia coli was
Distinct phenotypic expression associated with a new hyperunstable alpha globin variant (Hb heraklion, alpha1cd37(C2)Pro>0): comparison to other alpha-thalassemic hemoglobinopathies.
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Clinical phenotypes associated with abnormal globin chain biosynthesis may result in thalassemia (deficient quantity) or hemolytic anemia (abnormal hemoglobins). However, the phenotypic expression of hyperunstable hemoglobin variants often includes features of thalassemia, along with variable
[Novel neuroprotective agents: a HIF activator and an Akt activator].
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We here presented two new neuroprotective agents; a HIF activator and an Akt activator. Hypoxia inducible factor (HIF) plays a pivotal role in the adaptation to ischemic conditions, and its activity is modulated by an oxygen-dependent hydroxylation of proline residues by prolyl hydroxylases (PHD).
Hb Southampton [beta106(G8)Leu-->Pro, CTG-->CCG] in an Argentinean boy.
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Hb Southampton (also known as Hb Casper) is characterized by the substitution of a leucine residue for a proline at codon beta106 (CTG-->CCG). This mutation breaks the G helix and severely distorts the tertiary structure of the molecule, producing an unstable hemoglobin (Hb) and severe hemolysis. We
Probing the relationships between the structure and hemolytic activity of melittin with a complete set of leucine substitution analogs.
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We have investigated the effects on the hemolytic activity of the 26 individual amino acids making up melittin's sequence using a complete set of synthetic leucine substitution analogs. The relative dose to cause 50% hemolysis (HD50) for each analog was determined. Lysine-7 and tryptophan-19 were
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