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Pre-S.sub.2 Antigen protein can express polymerized human serum albumin binding activity (PHSA-BA). (A. Machida et al. A polypeptide containing 55 amino acid residues coded by the pre-S region of hepatitis B virus deoxyribonucleic acid bears the receptor for polymerized human as well as chimpanzee
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The invention relates to a complex comprised of an insoluble polymer carrier to which human albumin is covalently bound and of a pre-S hepatitis B surface antigen (pre-S-HBsAg) as well as to a method for the purification of pre-S-HBsAg.
From EP-A2-0 243 103, a method of purifying pre-S-HBsAg is
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The invention relates to a complex comprised of an insoluble polymer carrier to which human albumin is covalently bound and of a pre-S hepatitis B surface antigen (pre-S-HBsAg) as well as to a method for the purification of pre-S-HBsAg.
From EP-A2-0 243 103, a method of purifying pre-S-HBsAg is
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The invention relates to a complex comprised of an insoluble polymer carrier to which human albumin is covalently bound and of a pre-S hepatitis B surface antigen (pre-S-HBsAg) as well as to a method for the purification of pre-S-HBsAg.
From EP-A2-0 243 103, a method of purifying pre-S-HBsAg is
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FIELD OF INDUSTRIAL UTILITY
This invention relates to novel proteins useful as vaccines and a method of producing the same.
BACKGROUND ART
Type B hepatitis is a viral disease which occurs frequently in particular in the tropics of Africa, in Southeast Asia and in the Far East. Hepatitis B is
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FIELD OF INDUSTRIAL UTILITY
This invention relates to novel proteins useful as vaccines and a method of producing the same.
BACKGROUND ART
Type B hepatitis is a viral disease which occurs frequently in particular in the tropics of Africa, in Southeast Asia and in the Far East. Hepatitis B is
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The present invention relates to hepatitis B vaccine.
On a world-wide scale, the infection with hepatitis B virus (HBV) represents one of the major problems in public health care. There are an estimated 200 million persons who are carriers of HBV. These carriers are mostly asymptomatic, that is,
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FIELD OF THE INVENTION
The invention relates to a method for isolating and purifying pre-S2 containing hepatitis B virus surface antigen (HBsAg) from the plasma of a carrier of HBsAg characterized by the use of polymerized human serum albumin (pHSA)-affinity column chromatography, comprising the
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TECHNICAL FIELD
The present invention relates generally to the antigen HBcAg from hepatitis B virus (HBV) complexed to a second protein, antibodies against such a complexed HBcAg, and to methods and compositions for the detection of such a complexed HBcAg. The methods and compositions are also
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BACKGROUND OF THE PRESENT INVENTION
1. Field of Invention
The subject invention relates generally to a series of natural pharmaceutical preparations which can treat hypoproteinemia for increasing albumin. The preparations could be used to treat hypoproteinemia caused by hepatitis virus, human
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The invention concerns a composition useful for the fabrication of vaccines, containing or formed by approximately spherical polypeptide particles, at least as concerns most of them, these particles having immunogenic and immunologic properties characteristic of the surface antigen of the virus of
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The invention concerns a composition useful for the fabrication of vaccines, containing or formed by approximately spherical polypeptide particles, at least as concerns most of them, these particles having immunogenic and immunologic properties characteristic of the surface antigen of the virus of
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1. INTRODUCTION
The present invention relates to the propagation of human hepatocytes in the livers of non-human animals that have been tolerized to the human cells. Such animals provide an in vivo model system of the human liver that may be used in toxicology assays and in the study of human liver
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