histiocytoma/protease

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Intracytoplasmic crystalloid structures in a malignant fibrous histiocytoma: ultrastructural and cytochemical study.

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Crystalloid structures were frequently observed in the cytoplasm of the tumor cells of a malignant fibrous histiocytoma arising in the left leg of a 71-year-old female. These structures were located in the cytoplasm of the fibroblastlike and histiocyte-like tumor cells. The structures consisted of

Widespread immunoreactivity for alpha-1-antichymotrypsin in different types of tumors.

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The presence of alpha-1-antichymotrypsin (AACT) immunoreactivity was investigated in a broad range of different tumors. Because optimal AACT immunoreactivity of histiocytes was achieved by use of a protease pretreatment of paraffin sections, all tumors were studied by using pepsin treatment of the

Caspase-mediated apoptosis in AK-5 tumor cells: a cell-free study using peptide inhibitors and antisense strategy.

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An in vitro system has been employed to study the apoptotic mechanisms in the AK-5 tumor which is a spontaneously regressing rat histiocytoma. Cytosolic extracts of tumor cells primed for apoptosis using dexamethasone and immune serum from tumor-regressing animals were able to induce apoptosis in

2B1 antigen characteristically expressed on extracellular matrices of human malignant tumors is a large chondroitin sulfate proteoglycan, PG-M/versican.

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2B1 is a monoclonal antibody against a large proteoglycan isolated from human yolk sac tumor (M. Sobue et al., Histochem. J., 21: 455-460, 1989). The antigen is expressed in a variety of embryonal tissues as well as most if not all malignant tumor tissues. However, the expression in normal adult

Participation of CED-3/ICE and YAMA proteinases in the execution of apoptosis in AK-5 tumor cells leading to spontaneous tumor regression.

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AK-5, which is a spontaneously regressing rat histiocytoma, is killed by necrosis (perforin mediated) and apoptosis. We have studied the induction of apoptosis in AK-5 tumor cells by each of the following: a factor from anti-AK-5 antiserum, dexamethasone, and natural killer cells. Partial inhibition

Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours.

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OBJECTIVE Fibroblast activation protein (FAP)/seprase and dipeptidylpeptidase-IV (DPP-IV)/CD26 are serine integral membrane proteases. They are involved in tissue remodelling, cancer invasion and metastases, mechanisms that are controversial. The aim was to identify cell types that express FAP and

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