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hydrocarbon/sarcome
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Association between aryl hydrocarbon receptor genotype and survival in soft tissue sarcoma.
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OBJECTIVE
Accumulating evidence shows that germline polymorphisms may affect survival in cancer. The purpose of this study was to investigate the association between polymorphisms in a group of candidate genes and survival with soft tissue sarcoma.
METHODS
We measured single nucleotide polymorphisms
[Sex differences in susceptibility to production of sarcomas by polycyclic hydrocarbons in mouse XVII].
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Specific chromosome changes in malignancy: studies in rat sarcomas induced by two polycyclic hydrocarbons.
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The induction of sarcomas in the colon of rats by intraluminal application of hydrocarbons.
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Polycyclic hydrocarbon-induced rat sarcomas correlated to disturbances in the deoxyadenylate regions of the tumor DNAs.
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Relationships between aryl hydrocarbon hydroxylase inducibility and sensitivity to chemically induced subcutaneous sarcomas in various strains of mice.
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Inherited susceptibility of inbred strains of Syrian hamsters to induction of subcutaneous sarcomas and mammary and gastrointestinal carcinomas by subcutaneous and gastric administration of polynuclear hydrocarbons.
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Biological activities of dihydrodiols derived from two polycyclic hydrocarbons in rodent test systems.
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Comparisons have been made between (a) the initiation of tumours in mouse skin, (b) the induction of hyperplasia and the suppression of sebaceous glands in mouse skin and (c) the induction of s.c. tumours in rats, by either benzo[a]pyrene or 7-methylbenz[a]anthracene and their related K-region and
[Carcinogenic action of soot extracts and the composition of the aromatic polycyclic hydrocarbons in emissions of the coke chemical industry].
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Carcinogenicity of the extract of "unorganized" emission of coke-oven batteries of the coke and by-product processes, 15 polycyclic hydrocarbons (PAH), solution of 4 carcinogenic PAH and benz(a)pyrene (BP) was studied in longterm experiments on (CBAXC57Bl/6)F1 hybrid mice. 1.5 ml of olive oil
Intraperitoneal mesotheliomas induced in mice by a polycyclic aromatic hydrocarbon.
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Female mice of 6 strains (C3H/HeN, BALB/c, C57BL/6N, DBA/2, NIH Swiss, and AKR/N) were given the polycyclic aromatic hydrocarbon carcinogen 3-methylcholanthrene (MC) intragastrically in olive oil at a dose of 20 mg/kg, weekly for 12 wk. Half were pretreated 24 h before each MC administration with
Fusion of the AHRR and NCOA2 genes through a recurrent translocation t(5;8)(p15;q13) in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genes.
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Soft tissue angiofibroma is a recently delineated tumor type of unknown cellular origin. Cytogenetic analysis of four cases showed that they shared a t(5;8)(p15;q13). In three of them it was the sole change, underlining its pathogenetic significance. FISH mapping suggested the involvement of the
Contribution of polycyclic aromatic hydrocarbons to the carcinogenic impact of gasoline engine exhaust condensate evaluated by implantation into the lungs of rats.
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An attempt was made to identify the substances chiefly responsible for the carcinogenicity of gasoline engine exhaust condensate. A carcinogen-specific bioassay was performed by a comparison of the carcinogenic effect of various fractions with that of a total sample of automobile exhaust condensate,
Rank order of sarcoma susceptibility among mouse strains reverses with low concentrations of carcinogen.
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Ten mouse strains in which aryl hydrocarbon hydroxylase can be induced, or F1 hybrids of these strains, were ranked according to their sarcoma susceptibility when exposed to a high concentration (5 percent) of the chemical carcinogen 3-methylcholanthrene. This rank order was reversed when the
Chemical transformation of human revertant cells induced by murine sarcoma virus.
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A human revertant cell line, derived from non-producer human osteosarcoma cells (NP/KHOS) induced by Kirsten murine sarcoma virus, was treated in vitro with various levels of polycyclic aromatic hydrocarbons (3-methylcholanthrene, 7,12-dimethylbenz(alpha)anthracene, and benzo(alpha)pyrene [BP] or
Manganese inhibition of sarcoma induction by benzo[a]pyrene in rats.
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The effects of Mn and Cr dusts upon carcinogenesis by polycyclic aromatic hydrocarbons were tested in male Fischer 344 rats. In Experiment I, rats were given i.m. injections of benzo[a]pyrene (BP, 1.2 mg), Mn dust (4.4 mg), and Cr dust (4.4 mg), alone, and in various combinations. By 100 weeks,
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