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hypersensitivity/albumine

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Characterization of bovine serum albumin epitopes and their role in allergic reactions.

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OBJECTIVE This review provides updated information on conformational and sequential epitopes identified in bovine serum albumin (BSA) and summarizes available data about the role of structural modifications on BSA antigenicity/allergenicity. METHODS Data on beef allergy and BSA antigenicity are

Structure and stability of 2S albumin-type peanut allergens: implications for the severity of peanut allergic reactions.

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Resistance to proteolytic enzymes and heat is thought to be a prerequisite property of food allergens. Allergens from peanut (Arachis hypogaea) are the most frequent cause of fatal food allergic reactions. The allergenic 2S albumin Ara h 2 and the homologous minor allergen Ara h 6 were studied at

Purified natural and recombinant Fel d 1 and cat albumin in in vitro diagnostics for cat allergy.

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BACKGROUND Current diagnostics and therapeutics for cat allergy are based on cat epithelial extracts originating from highly variable source materials. This gives rise to several problems: variability of allergen composition, contamination with house dust mite allergens, and potential transfer of
Delayed hypersensitivity (DH) was induced in the footpads of mice sensitized to methylated bovine serum albumin (MBSA). The magnitude of this DH response increased with increasing sensitizing concentration of MBSA. Levamisole administered 1 hr prior to MBSA challenge stimulated the DH response and

Allergy to sesame in humans is associated primarily with IgE antibody to a 14 kDa 2S albumin precursor.

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The goal of this study was to identify and characterise the major allergen(s) of sesame seed. Detection of specific IgE to sesame proteins was performed with Pharmacia CAP System and Western blotting, after separation of sesame proteins by SDS-PAGE, using sera from 28 subjects diagnosed as allergic
The injection of Cy before immunization provokes an intensification of delayed-type hypersensitivity (DTH) to methylated bovine serum albumin (M-BSA) and a diminution of about 90% of the cell number in various lymphoid tissues. The relationship between these observations, the time of administration,

Delayed-type hypersensitivity as revealed on the footpads of mice to azobenzenearsonate-acetyl bovine serum albumin.

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A strong delayed-type footpad reaction was established in mice using azobenzenearsonate-acetyl bovine serum albumin (ABA-AcBSA) as an antigen. Male ddY/S mice were sensitized by subcutaneous injection of 100 microliter of Freund's complete adjuvant - saline (1:1) emulsion containing 100 microgram of

The role of the wax of the tubercle bacillus in establishing delayed hypersensitivity, hypersensitivity to a protein antigen, egg albumin.

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Guinea pigs sensitized with egg albumin along with the purified wax fraction of the human tubercle bacillus respond with delayed hypersensitive reactivity to the protein antigen. Previous publications have reported a similar activity of the wax with respect to tuberculoprotein and picryl chloride.

An investigation of possible immunologic reactions to human serum albumin used as a stabilizer in allergy extracts.

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Two hundred fifteen patients who had received allergy immunotherapy for at least 1 year with an extract preparation containing 0.03% human serum albumin (HSA) were tested for evidence of an immunologic reaction to HSA by immediate skin testing. Sera from 39 of these subjects and from control

Respiratory allergy induced by exclusive polysensitization to serum albumins of furry animals.

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In this report we describe un unusual case of exclusive allergic sensitization to furry animals, as a possible study model to speculate about different modalities ofsensitization to allergens of common and less common mammalian species. A 27-year-old woman referred in our Allergological Centre for

[Metabolomics of bovine serum albumin-induced allergic reactions based on UPLC-Q-TOF-MS].

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The metabonomic techniques were used to study the changes in endogenous metabolites between urines of rats in normal physiological conditions and bovine serum albumin induced allergic reactions, identify potential biomarkers associated with allergic reactions, and then analyze the metabolic pathways
Delayed-type hypersensitivity (DTH) to the random copolymers poly(Glu50Tyr50) (GT) or poly(Glu60Ala30Tyr10) (GAT) could be produced in BALB/c mice when the polymers were injected complexed to a methylated bovine serum albumin (mBSA). The pretreatment with GT or with mBSA 4 days before the
BACKGROUND The aim of this paper was to investigate the role of SLPI in patients with allergic rhinitis. From this point of view, we also examined leukocyte elastase, alpha1-antitrypsin, and albumin. SLPI is an inhibitor of serine proteases such as leukocyte elastase, cathepsin G, and mast-cell
Sensitization to simple chemical substances acting as haptens is not well known in food allergy. For that purpose, a study was made in rabbit using tartrazine alone with adjuvant, or mixed with human serum albumin (HSA), or conjugated by covalent BOP bonds with HSA. Hypersensitivity was evaluated by

Preferential induction of memory T cells for delayed-type hypersensitivity with reduced and alkylated human serum albumin in mice.

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Reduction and alkylation of human serum albumin (HSA) resulted in molecular aggregation of the protein. The reduced and alkylated antigen (RA-HSA) was lacking in the ability to induce delayed-type hypersensitivity (DTH) response as well as antibody response to native HSA in mice, although native HSA
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