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Phenylenediamine derivative radical scavenger, brain-infarction depressant, and brain-edema depressant
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RELATED APPLICATIONS
This application is incorporating by reference Japanese Patent Application No. 7-344947 filed on Dec. 5, 1995, which has the laid open publication (JP09-157236) date of Jun. 17, 1997.
FIELD OF THE INVENTION
The present invention relates to a phenylenediamine derivative and, in
Pyrazolidine derivative radical scavenger brain-infarction depressant and brain-edema depressant
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FIELD OF THE INVENTION
The present invention relates to a pyrazolidine derivative and, in particular, to a derivative effective as a radical scavenger in organisms.
BACKGROUND OF THE INVENTION
In recent years, attention has been paid to influences of active oxygen and free radical upon organisms.
Phenylenediamine derivative, radical scavenger, brain-infarction depressant, and brain-edema depressant
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RELATED APPLICATIONS
None.
FIELD OF THE INVENTION
The present invention relates to a phenylenediamine derivative and, in particular, to a derivative effective as a radical scavenger in organisms.
BACKGROUND OF THE INVENTION
In recent years, attention has been paid to influences of active oxygen and
Methods of using L-butylphthalide for the prevention and treatment of cerebral ischemia disease
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FIELD OF THE INVENTION
The inventive subject matter relates to a new use of L-butylphthalide in the prevention and treatment of cerebral ischemia-induced diseases, particularly to a use of L-butylphthalide in manufacturing the medicaments for the prevention and treatment of cerebral ischemia-induced
Prodrug salts
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TECHNICAL FIELD
Provided are novel prodrug salts of selective aquaporin inhibitors, e.g., of aquaporin-4 and/or aquaporin-2, of Formula I as described below, their use as pharmaceuticals and pharmaceutical compositions comprising them, and novel intermediates used in and novel processes for their
Prodrug salts
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TECHNICAL FIELD
Provided are novel prodrug salts of selective aquaporin inhibitors, e.g., of aquaporin-4 and/or aquaporin-2, of Formula I as described below, their use as pharmaceuticals and pharmaceutical compositions comprising them, and novel intermediates used in and novel processes for their
Use of timosaponin Bll in the preparation of a medicament or product for the prevention and treatment of stroke
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TECHNICAL FIELD
The present invention relates to use of timosaponin BII, in particular the use of timosaponin BII in the preparation of a medicament or product for the prevention and treatment of stroke (apoplexy).
BACKGROUND ART
Stroke (apoplexy) involves sudden loss of neural function due to
Pyrazolopyridine compound and processes for preparation thereof
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The present invention relates to novel pyrazolopyridine compound and a pharmaceutically acceptable salt thereof.
More particularly, it relates to novel pyrazolopyridine compound and a pharmaceutically acceptable salt thereof, which are adenosine antagonists and possess various pharmaceutical actions
Indolylmaleimide derivatives
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The present invention relates to indolylmaleimide derivatives, process for their production and pharmaceutical compositions containing them.
More particularly the present invention provides a compound of formula I
##STR00002## wherein R.sub.a is H; CH.sub.3; CH.sub.2--CH.sub.3; or isopropyl, R.sub.b
Indolylmaleimide derivatives
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The present invention relates to indolylmaleimide derivatives, process for their production and pharmaceutical compositions containing them.
More particularly the present invention provides a compound of formula I
##STR00002## wherein
R.sub.a is H; CH.sub.3; CH.sub.2--CH.sub.3; or isopropyl,
R.sub.b
Inhibitor of vascular permeability enhancer
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a method for preventing or treating a brain edema, an intracranial hemorrhage (especially a recurrence of an intracranial hemorrhage and so on) and a cerebral infarction, which comprises administering a
Methods of screening for compounds which bind G protein-coupled receptors
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is the 35 U.S.C. .sctn.371 national stage of PCT application PCT/JP2005/007354, filed Apr. 11, 2005, which claims priority to Japanese patent application No. 116725/2004, filed Apr. 12, 2004. The contents of these applications are incorporated
Treatment of cerebral disorders by inhibition of IL-8 binding to receptor
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TECHNICAL FIELD
The present invention relates to a preventive or therapeutic agent for cerebral stroke comprising an interleukin-8 (IL-8)-binding-inhibition agent as an active ingredient. The present invention also relates to a preventive or therapeutic agent for cerebral edema comprising an
Protein S protects the nervous system from injury
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BACKGROUND OF THE INVENTION
This invention relates to the use of protein S and/or variants thereof as neuroprotective agents for treating brain disorders and other pathological conditions. The ability of protein S and variants thereof to act as cell survival factors on cells of the nervous systems
Protecting and survival promoting agent for central nervous cell
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TECHNICAL FIELD
The present invention relates to an agent for protecting central nerve cells and enhancing survival thereof
BACKGROUND ART
Hippocampal neurons have widely been used in the field of the neurophysiology as central nerve cells that can be cultured in laboratories. It has been known that
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