Compositions containing microparticles loaded with one or protease enzymes and optionally auxiliary therapeutic agents and methods of treating conditions such as keloids therewith are disclosed. The biodegradable polymer and the protease enzyme therein form a controlled release matrix for extended release of the enzyme after administration to a mammal in need thereof.

Hyalo Technologies, LLC

HYALO TECHNOLOGIES, LLC

Composition and method of preparation of protease microparticulate slow release preparation

The present invention provides methods for treating pruritus by blocking human protease activated receptor-2 (PAR2) activity. The methods of the invention can be used to treat pruritus associated with atopic dermatitis, psoriasis, burn scarring, hypertrophic scarring, keloids, renal failure or hepatic failure. The methods of the invention include administering an antibody or antigen-binding fragment thereof that specifically binds human PAR2.

MacDonald; Lynn

Murphy; Andrew J.

Papadopoulos; Nicholas J.

Morra; Marc R.

Salzler; Robert R.

LaCroix-Fralish; Michael L.

Regeneron Pharmaceuticals, Inc.

Methods for treating pruritus by administering an antibody that specifically binds human PAR2

The method for preventing and for treating mammalian cicatrices such as keloids, acne scars, hypertrophic scars, wrinkles, cellulite and neoplastic fibrosis which comprises intra-dermal injection of effective amounts of a pharmacologically suitable solution of the enzymes collagenase, elastase, papain, plasminogen activator, plasmin, mast cell protease or lysosomal hydrolase, individually, and one or more of such enzymes in combination with the enzyme hyaluronidase.

Biospecifics, NV

Method for the prevention and treatment of scars with enzymes

By the combined use of an agent which selectively dissolves tumor cells and which contains a protein fraction which has oxygen-liberating action and which is derived from the photosynthetic system of plants, together with a further agent which inhibits the proteases of the cancer cells and which has been obtained by means of extraction of embryonic tissue or maternal uterus tissue from placentals, it is possible to selectively dissolve the tumor by means of this agent without damaging the healthy organism. When used on its own, the abovementioned plant-derived agent shows an activity in the treatment of inflammatory processes and is also suitable for the aftertreatment of scars, keloids and damage caused by ionizing rays.

Method for the selective dissolution of cancer cells using a composition derived from the photosynthetic system of plants and mammalian embryonic tissue

keloid

protease

keloid/protease

Composition and method of preparation of protease microparticulate slow release preparation

Methods for treating pruritus by administering an antibody that specifically binds human PAR2

Method for the prevention and treatment of scars with enzymes

Method for the selective dissolution of cancer cells using a composition derived from the photosynthetic system of plants and mammalian embryonic tissue

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