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[Effects of lanthanum chloride on proliferation and migration of human cervical cancer cell line HeLa cells].
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OBJECTIVE
To investigate the effects of lanthanum chloride on proliferation and migration activity of human cervical cancer cells in vitro which may be a new anti-cervical cancer drug and provide experimental data for cervical cancer treatment.
METHODS
HeLa cells cultured in vitro were divided into
Metabolizable lanthanum-coordination nanoparticles as efficient radiosensitizers for solid tumor therapy.
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The clinical potential of radiotherapy cannot be realised as expected due to the inherent radioresistance of tumors. To overcome these problems, radiosensitizers containing heavy metal elements have been used in radiotherapy as efficient radiation dose enhancers. In the present study, we report the
Blood tumor permeability of experimental brain tumor: an electron microscopic study using lanthanum.
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In an attempt to assess the permeability of microvessels in the experimental brain tumor model, lanthanum ion (La3+) was used as a low-molecular weight electron microscopic probe. Rat glioma 9 L and adenocarcinoma ACL15 were transplanted to the brain and subflank of rats. The rats were then
[Effects of lanthanum and cerium on malignant proliferation and expression of tumor-related gene].
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Cultured human gastric cancer cell line PAMC82 was studied in vitro to further verify anti-tumor effect sof rare-earth elements and explore their mechanism of tumor inhibition. Inhibitory effects of elements lanthanum and cerium on cell growth, reverse effects of them on reduction of malignancy and
Enhancement of hematoporphyrin derivative uptake in vitro and in vivo by tumor cells in the presence of lanthanum.
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Hematoporphyrin derivative is currently used as a photochemotherapeutic agent in the treatment of neoplasms. The uptake of hematoporphyrin derivative was determined in vitro and as a function of time with Ehrlich ascites cells in the presence of lanthanum and in vivo with VFM1, tumor-bearing mice
Case of early-stage gastric cancer identified in the gastric mucosa with lanthanum phosphate deposition.
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Background and study aims A 78-year-old man with Helicobacter pylori infection had been undergoing hemodialysis for chronic renal failure and receiving lanthanum carbonate preparations for 3 years. Endoscopy revealed fine white granular discoloration throughout the stomach, a
Biological activities of siRNA-loaded lanthanum phosphate nanoparticles on colorectal cancer
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Lanthanum can reduce absorption of phosphate by forming lanthanum phosphate complexes after oral administration of lanthanum carbonate tablets (FOSRENOL®) in patients. Based on the pH-responsive interaction of phosphate and lanthanum ions, the chitosan coated siRNA-loaded lanthanum phosphate
Anti-cancer study and whey protein complexation of new lanthanum(III) complex with the aim of achieving bioactive anticancer metal-based drugs.
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In this study, a new lanthanum (III)-amino acid complex utilizing cysteine has been synthesized and characterized. The anticancer activities of the prepared La(III) complex against MCF-7 cell lines were studied. Results of MTT assay showed that at all three incubation times, the cytotoxic effect of
Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24).
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Recently, we have introduced [tris(1,10-phenanthroline)lanthanum(III)] trithiocyanate (KP772, FFC24) as a new lanthanum compound which has promising anticancer properties in vivo and in vitro. Aim of this study was to investigate the impact of ABC transporter-mediated multidrug resistance (MDR) on
The effects of lanthanum chloride on proliferation and apoptosis of cervical cancer cells: involvement of let-7a and miR-34a microRNAs.
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Lanthanide elements have been documented to possess various biologic effects, and their compounds have been studied intensely for their anti-cancer potential. However, the underlying mechanisms remain largely unknown. In the present study, we propose that the levels of proliferation and apoptosis
Facile fabrication of a novel 3D rose like lanthanum doped zirconia decorated reduced graphene oxide nanosheets: An efficient electro-catalyst for electrochemical reduction of futuristic anti-cancer drug salinomycin during pharmacokinetic study.
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An innovative electrochemical nanoprobe, for analysis of salinomycin (SAL), was proposed. The nanoprobe based on decoration of glassy carbon electrode (GCE) with 3D rose like La3+@ ZrO2 supported on reduced graphene oxide (RGO) nanosheets. The 3D rose like La3+@
Experimental evidence for the probable involvement of calcium ion transport in 67Ga uptake by tumour cells.
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The study of 67Ga-citrate uptake and calcium transport in Ehrlich ascites tumour cells seems to indicate that their peculiar characteristic of increased permeability to extracellular calcium ion might be responsible for their 67Ga accumulation. Experiments performed under different conditions of
The influence of methylprednisolone on the energy metabolism of Ehrlich ascites tumour cells.
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Using Ehrlich ascites tumour cells, the short-term effects of the therapeutic glucocorticoid Methylprednisolone (MP) on the cellular energy metabolism were studied. ATP-consuming processes involved in the rapid MP effects were identified indirectly from the effects of MP on cellular oxygen
A Lanthanum-Tagged Chemotherapeutic Agent HA-Pt to Track the In Vivo Distribution of Hyaluronic Acid Complexes.
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Hyaluronic acid drug conjugates can target anti-cancer drugs directly to tumor tissue for loco-regional treatment with enhanced bioavailability, local efficacy and reduced toxicity. In this study, the distribution and pharmacokinetics of hyaluronic acid carrier and a conjugated cisplatin anti-cancer
Construction of high quality ultrathin lanthanide oxyiodide nanosheets for enhanced CT imaging and anticancer drug delivery to efficient cancer theranostics.
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Two-dimensional (2D) ultrathin nanomaterials have shown extensive attention and potential biomedical applications in cancer theranostics. Herein, for the first time, we report the synthesis of monodisperse ultrathin lanthanum oxyiodide (LaOI) nanosheets with a thickness of merely 3 nm based on a
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