lecithin/crise épileptique

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[Influence of phosphatidylcholine on the threshold dose of pentylenetetrazol for inducing seizure].

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Because of its putative long-acting cholinomimetic property, phosphatidylcholine (Pc, lecithin), is expected to have a therapeutic efficacy on states in which a cholinergic hypofunction in the CNS is pathognomonic. Cholinomimetic drugs in general have been reported to enhance proconvulsive

1-O-alkylglycerol stabilized carbamazepine intravenous o/w nanoemulsions for drug targeting in mice.

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Carbamazepine (CBZ) is used in the treatment of generalized tonic clonic and partial seizures. In seizure disorder the focal point of treatment is brain. At present no commercial parenteral formulation of CBZ is available. We developed o/w nanoemulsions of CBZ stabilized by

Influence of perfluorocarbons on Carbamazepine and Benzodiazepine for a neuro-lung protective strategy.

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Lennox-Gastaut syndrome (LGS) is commonly characterized by a triad of features including multiple seizure types, intellectual disability or regression. LGS type of seizures is epilepsy which is due to abnormal vibrations occurring in seizures. During the time of such abnormal vibrations, both the

Therapeutic serum phenobarbital concentrations obtained using chronic transdermal administration of phenobarbital in healthy cats.

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Seizures are a common cause of neurologic disease, and phenobarbital (PB) is the most commonly used antiepileptic drug. Chronic oral dosing can be challenging for cat owners, leading to poor compliance. The purpose of this study was to determine if the transdermal administration of PB could achieve

Preeclampsia associated with hemolysis, elevated liver enzymes, and low platelets--an obstetric emergency?

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A study was undertaken of 27 patients with severe preeclampsia who had hemolysis, liver enzyme elevation, and thrombocytopenia as described by Weinstein. In addition to this triad, all patients exhibited the symptoms and signs of pregnancy-induced hypertension by which the diagnosis is usually

Safety assessment of AGPC as a food ingredient.

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α-Glycerylphosphorylcholine (AGPC) is a semi-synthetic derivative of lecithin. Following oral administration, it is converted to phosphatidylcholine, a metabolically active form of choline that is able to reach cholinergic synaptic endings where it increases acetylcholine synthesis and release. A

Neonatal outcomes after demonstrated fetal lung maturity before 39 weeks of gestation.

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OBJECTIVE To compare outcomes among neonates delivered after documentation of fetal lung maturity before 39 weeks and those delivered at 39 or 40 weeks. METHODS This was a retrospective cohort study of women with singleton pregnancy delivered at 36 0/7 to 38 6/7 weeks after positive fetal lung

Liposome toxicity in the mouse central nervous system.

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This study has shown that while some liposomes are highly toxic to the central nervous system, others, of different composition, are tolerated well in the dosage used (0.02-0.05 ml = 4-12 mg of lipid/inoculum). Those composed of lecithin-cholesterol-dicetyl phosphate or

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