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leukocytosis/phosphatase
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Chronic myelogenous leukemia with elevated leukocyte alkaline phosphatase, positive indirect Coombs' test, neutrophilic leukocytosis and unusual cytogenetical findings.
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An unusual case of chronic myelogeous leukemia (CML) is reported which was characterized by leukocytosis without a shift to the left, elevated leukocyte alkaline phosphatase, positive indirect Coombs' test, anemia and thrombocytosis, as well as the absence of hepatosplenomegaly. The diagnosis of CML
Increased expression of tyrosine phosphatase SHP2 in experimental pneumococcal meningitis: correlation with tumor necrosis factor-alpha and cerebrospinal fluid pleocytosis.
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Protein tyrosine phosphatase SHP2 plays a crucial role in the development of the central nervous system. To explore the expression and possible role of SHP2 during the course of bacterial meningitis, this article reports a juvenile rat bacterial meningitis model established by direct intracisternal
Bronchogenic carcinoma with adrenal metastases and leukemoid reaction: probable noncontribution of leukocytosis to elevated serum alkaline phosphatase.
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Leukocytosis associated with low leukocyte alkaline phosphatase score following intravenous steroid therapy for atopic dermatitis.
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[Cytochemistry of leukocytosis. 3. Leukocyte alkaline phosphatase (LAP). 1. Cytochemical method of determination].
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Alkaline phosphatase activity of the polymorphonuclear leukocyte in rapidly induced leukopenia and leukocytosis.
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Isolated thrombocytosis in chronic myeloid leukemia without significant leukocytosis.
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Chronic myeloid leukemia (CML) typically causes leukocytosis rather than thrombocytosis. We encountered two women in their thirties with remarkable thrombocytosis, whose platelet counts were over 3,000×103/µl, and without significant leukocytosis. Although their clinical findings resembled that of
The level of serum granulocyte colony-stimulating factor in cancer patients with leukocytosis.
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The level of serum granulocyte colony-stimulating factor (G-CSF) obtained from patients with leukocytosis (greater than 10,000/microliters) between May 1989 and April 1991 was measured by enzyme immunoassay. Studied were 18 patients with malignant neoplasms (median age, 64 years) and 14 patients
Erythrocytosis and marked leukocytosis in overlapping myeloproliferative diseases.
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We describe two patients who had similar features of erythrocytosis and marked leukocytosis but who were subsequently classified as having chronic myelogenous leukemia and polycythemia vera, respectively, using leukocyte alkaline phosphatase scores and cytogenetic studies to detect the Philadelphia
A possible mechanism of increase in serum alkaline phosphatase activity in rats given granulocyte colony-stimulating factor.
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Recombinant human granulocyte colony-stimulating factor (G-CSF) at a dose of 1 to 300 micrograms/kg/day was administered intravenously to rats daily for 13 weeks. Serum alkaline phosphatase (ALP) activity increased dose-dependently with leukocytosis. Most of the increased leukocytes were segmented
Absent neutrophil alkaline phosphatase in the eosinophilia myalgia syndrome associated with L-tryptophan use.
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The clinical constellation of leukocytosis, thrombocytosis, and low or absent stainable neutrophil alkaline phosphatase (NAP) is considered characteristic of chronic myelogenous leukemia (CML). CML with eosinophilic differentiation (eosinophilic leukemia) is well described, and leukemia and other
[A case of left atrial myxoma with remarkable elevation of serum alkaline phosphatase level].
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A 53-year-old woman was admitted suffering from high grade fever. Laboratory findings revealed leukocytosis, high CRP, high erythrocyte sedimentation rate and remarkable elevation of serum alkaline phosphatase level. Echocardiogram demonstrated left atrial tumor which was later diagnosed as myxoma.
Activity of acid and alkaline phosphatase in neutrophils of rats exposed to benzene and treated with selenium.
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Cytochemical studies on activity of acid phosphatase (AcP) and alkaline phosphatase (AP) in peripheral blood neutrophils of rats chronically exposed to benzene vapours (1,200 mg/cm3) demonstrated that the exposure results in the increase of AcP and the decrease of the AP activity. The changes noted
Excess leukocytosis (leukemoid reactions) associated with malignant diseases.
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Twenty-one patients with malignancy had a peripheral white blood cell count of 50,000/cu mm or more. The malignancies arose from several tissues, especially lung; all were carcinomas except for one osteogenic sarcoma. In no case was there evidence of leukemia as defined by disorderly marrow growth,
A G-CSF-secreting adrenal carcinoma with rhabdoid-like differentiation causing leukocytosis.
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BACKGROUND
A 57-year-old African American man presented to a tertiary care center with a 6-month history of fatigue and worsening abdominal pain. He had lost 9.1 kg in weight in the 3 months leading up to presentation, and described subjective fevers and night sweats for 1 month with a nonproductive
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