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BACKGROUND OF THE INVENTION
This invention relates to benzothiophenes, particularly, 3-hydroxybenzo[b]thiophene-2-carboxamides, which are found to be effective cyclooxygenase and 5-lipoxygenase inhibitors and are therefore useful in the treatment of inflammation and other prostaglandin and
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BACKGROUND OF THE INVENTION
This invention relates to fused heterocyclic carboxamides, for example, N-(2,2-diphenylethenyl)-3-hydroxythieno[3,2-b]thiophene-2-carboxamide.
These novel compounds are found to be effective cyclooxygenase and 5-lipoxygenase inhibitors and are therefore useful in the
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is related to commonly assigned U.S. application Ser. Nos. 578,413, abandoned, for "Tumor Reducing Compositions," Allen, and 578,412, abandoned, "Antioxidant Compounds and Methods of Synthesis," Allen, et al., being filed in the U.S. Patent
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BACKGROUND OF THE INVENTION
This invention relates to benzothiophenes, particularly 2-hydroxybenzothiophenes having the unusual 3-enamido side chains, for example, ##STR1##
These novel compounds can be effective cyclooxygenase and 5-lipoxygenase inhibitors and therefore can be useful in the
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BACKGROUND OF THE INVENTION
This invention relates to benzothiophenes, particularly 3-hydroxybenzothiophenes having the unusual 2-enamido side chains, for example, ##STR1##
These novel benzothiophenes are found to be effective cyclooxygenase and 5-lipoxygenase inhibitors and are therefore useful in
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BACKGROUND OF THE INVENTION
This invention relates to 3-hydroxyazabenzothiophenes having the 2-position substituted with an optionally substituted aryl, aralkyl, alkyl, or alkenyl group, for example, 3-acetyloxy-7-aza-2-phenyl-benzo[b]thiophene.
These novel azabenzothiophenes are found to be either
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BACKGROUND OF THE INVENTION
This invention relates to 3-hydroxyazabenzothiophenes having the 2-position substituted with an optionally substituted aryl, aralkyl, alkyl, or alkenyl group, for example, 3-acetyloxy-7-aza-2-phenyl-benzo[b]thiophene.
These novel azabenzothiophenes are found to be either
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BACKGROUND OF THE INVENTION
This invention relates to 3-hydroxyazabenzothiophenes having the 2-position substituted with an optionally substituted aryl, aralkyl, alkyl, or alkenyl group, for example, 3-acetyloxy-7-aza-2-phenyl-benzo[b]thiophene.
These novel azabenzothiophenes are found to be either
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BACKGROUND OF THE INVENTION
This invention relates to benzothiophenes, particularly 3-hydroxybenzothiophenes having the unusual 2-enamido side chains, such as those of Formula I: ##STR2##
Compounds of formula I have been found to be effective inhibitors of both cyclooxygenase and lipoxygenase and
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BACKGROUND OF THE INVENTION
The present invention is novel compounds which are 3,5-di-tertiary-butyl-4-hydroxyphenyl substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and
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BACKGROUND OF THE INVENTION
The present invention is novel compounds which are 3,5-di-tertiary-butyl-4-hydroxyphenyl substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and
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BACKGROUND OF THE INVENTION
The present invention is novel compounds which are 3,5-di-tertiary-butyl-4-hydroxyphenyl substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoes, and 1,2,4-triazoles, and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and
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BACKGROUND OF THE INVENTION
The present invention is novel compounds which are 2-substituted-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now
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BACKGROUND OF THE INVENTION
The present invention is novel compounds which are 2-substituted amino-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds
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BACKGROUND OF THE INVENTION
The present invention is a novel compound which is a thiadiazole or oxadiazole analog of a fenamic acid having a substituted hydroxamate side chain and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use thereof
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