Evaluation of cardiovascular risk factors, oxidative stress and fatty acid metabolism in a cohort of blood donors

Cardiovascular Disease

AVIS

Vascular Medicine Unit, Department of Medical Science and Biotechnology

Cardiovascular Risk Factors, Lipid Metabolism and Oxidative Stress

Relation Between Fatty Acids and Oxidative Stress Markers With Cardiovascular Risk Factors in a Healthy Population

Assessment of plasma reference values of the complete fatty acid profile, oxysterols and alpha- and gamma-tocopherol in healthy italian subjects

The assessment of the complete fatty acids profile, oxysterols and vitamin E (alpha- and gamma-tocopherol) would reveal associations with components cardiovascular risk factors of the metabolic syndrome

Prospective evaluation of cardiovascular events as function of baseline fatty acids and oxidative stress

Luigi Iuliano

M.D.

University of Roma La Sapienza

Mixed age and gender group of healthy volunteers for testing bio-availability of Lycopene containing supplement

Mixed age and gender group of healthy volunteers for testing bio-availability of Resveratrol containing supplement

Mixed age and gender group of healthy volunteers for testing bio-availability of Soy Isoflavones containing supplement

Babraham Research Campus

Bioavailability Study of Different Dietary Antioxidants in Volunteers

Phase 1 Bioavailability Study of Different Dietary Antioxidants in Volunteers

Medical Director Dr Ivan Petyaev

Cambridge Theranostics Ltd

Supplementation of tomato extract containing 28 mg/day for 12 months in addition to routine treatment.

Carotid Atherosclerotic Disease

Placebo

Tomato extract containing 28 mg lycopene/ day

Ateronon

Addenbrooke's Hospital

Supplementation of Lycopene in Carotid Atheroma

Supplementation of Lycopene on Carotid Atheroma: Neovascularisation and Morphology (SOLANUM) Study

Magnetic resonance imiging (MRI) of the plaques will be performed with detailed assessment of plaque morphological parameters: fibrous cap, lipid rich necrotic core, intraplaque hemorrhage. Sheer stress and wall stress will be calculated using magnetic resonance data.

Serum levels of lycopene obtained through long-time supplementation with a tomato extract containing lycopene.

Amount of microeboli detected using bilateral middle cerebral artery (MCA) TCD monitoring (DWL, Germany, 2-MHz probe). TCD will be performed by a single investigator (KPB) for 1 hour

Serum levels of total cholesterol, low-denisty lipoproteins (LDL), oxidized-LDL (oxy-LDL), high-density lipoproteins (HDL), C-reactive protein (CRP) as biomarkers of atherosclerosis

Levels of blood circulating endothelial cells and endothelial progenitor cells will be measured as markers for endothelial injury

Plaque enhancement on dynamic contrast-enhanced MRI perfusion imaging using gadolinium-based contrast agent as a surrogate marker for plaque inflammation and neovascularisation.

Karol Palwel Budohoski

Resident in Neurosurgery

Cambridge University Hospitals NHS Foundation Trust

Subarachnoid Hemorrhage

Aneurysm

Lycopene

placebo

Lycopene Following Aneurysmal Subarachnoid Haemorrhage

Acute Oral Lycopene Therapy on Cerebral Autoregulation and Delayed Ischaemic Deficits Following Aneurysmal Subarachnoid Haemorrhage (LASH): A Randomized Controlled Trial

lycopene/accident vasculaire cérébral

Cardiovascular Risk Factors, Lipid Metabolism and Oxidative Stress

Bioavailability Study of Different Dietary Antioxidants in Volunteers

Supplementation of Lycopene in Carotid Atheroma

Lycopene Following Aneurysmal Subarachnoid Haemorrhage

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