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Neutrophil-infiltrated paw edema induced by mannose-binding Dioclea violacea lectin.
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BACKGROUND
The potential edematogenic effect and the pharmacological characterization of a glucose-mannose-binding lectin from Dioclea violacea (DvL) were investigated.
METHODS
Paw edema was induced with DvL in control animals, and in animals pretreated with glucocorticoid or with blockers of
[Adherence to HEp-2 cells of enterotoxemic Escherichia coli O-group 139 from pigs with edema disease].
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One hundred and one strains of enterotoxemic Escherichia coli (ETEEC) O-group 139 isolated from swine with edema disease were investigated for their adherence to HEp-2 cells in the presence of D-mannose. All strains adhered in large numbers to the cells (21 to 60 bacteria/cell). No correlation was
Prevention of cyclophosphamide-induced hemorrhagic cystitis by glucose-mannose binding plant lectins.
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OBJECTIVE
Neutrophils are implicated in the physiopathologic alterations of hemorrhagic cystitis (HC). Thus, we decided to test the antiinflammatory activity of glucose-mannose binding lectins extracted from D. violacea and D. guianensis seeds, which showed an inhibitory effect upon neutrophil
Purification and molecular characterization of a novel mannose-specific lectin from Dioclea reflexa hook seeds with inflammatory activity.
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A novel lectin present in Dioclea reflexa seeds (DrfL) was discovered and described in this study. DrfL was purified in a single step by affinity chromatography in a Sephadex G-50 column. The lectin strongly agglutinated rabbit erythrocytes and was inhibited by α-methyl-D-mannoside, D-mannose, and
The differing roles of the classical and mannose-binding lectin complement pathways in the events following skeletal muscle ischemia-reperfusion.
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Complement is an important mediator of the injuries observed after skeletal muscle ischemia and subsequent reperfusion. Although the classical pathway had been assumed to be the major pathway of activation leading to injury, the mannose-binding lectin (MBL) pathway might also play a contributing
Lectin from Canavalia villosa seeds: A glucose/mannose-specific protein and a new tool for inflammation studies.
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With important carbohydrate binding properties, lectins are proteins able to decipher the glycocode, and as such, they can be used in bioassays involving cell-cell communication, protein targeting, inflammation, and hypernociception, among others. In this study, a new glucose/mannose-specific lectin
Involvement of mannose receptor in the preventive effects of mannose in lipopolysaccharide-induced acute lung injury.
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Although macrophage mannose receptor contributes to the anti-inflammatory procedure, its mechanisms of action are incompletely understood in acute lung injury. We recently found that mannose which could bind to mannose receptor, prevented acute lung injury in rats. Here, we profiled the involvement
Mannose binding lectin gene deficiency increases susceptibility to traumatic brain injury in mice.
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Mannose binding lectin (MBL) initiates complement activation and exacerbates tissue damage after systemic ischemia/reperfusion. We tested the hypothesis that MBL activates complement and worsens outcome using two levels of controlled cortical impact (CCI) in mice. After moderate CCI (0.6 mm depth),
A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation.
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Individuals with congenital disorders of glycosylation (CDG) have recessive mutations in genes required for protein N-glycosylation, resulting in multi-systemic disease. Despite the well-characterized biochemical consequences in these individuals, the underlying cellular defects that contribute to
Mannose prevents lipopolysaccharide-induced acute lung injury in rats.
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OBJECTIVE
To investigate the effect of mannose on lipopolysaccharide (LPS) induced acute lung injury (ALI) in rats.
METHODS
Ten groups of Sprague-Dawley rats were used: 1) the control group received an intratracheal instillation of saline, 2) the LPS group received an intratracheal instillation of
Multivalent Mannose-Decorated NIR Nanoprobes for Targeting Pan Lymph Nodes.
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Lymphadenectomy is a prerequisite for most malignancies to define the precise staging of cancer, as well as resect the possible metastases completely. While it improves prognosis, lymphadenectomy often causes postoperative edema or bleeding because of unclear surgical margins. In this study, we
Withaferin-A, a steroidal lactone encapsulated mannose decorated liposomes ameliorates rheumatoid arthritis by intriguing the macrophage repolarization in adjuvant-induced arthritic rats.
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In order to develop a better therapeutic approach for the treatment of rheumatoid arthritis (RA), withaferin-A; a steroidal lactone incorporated with mannosylated liposomes (ML-WA) was administered to adjuvant induced arthritic rats in intent to target the synovial macrophages. The confocal
Purification, characterization and partial sequence of a pro-inflammatory lectin from seeds of Canavalia oxyphylla Standl. & L. O. Williams.
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Recent studies have shown that lectins are promising tools for use in various biotechnological processes, as well as studies of various pathological mechanisms, isolation, and characterization of glycoconjugates and understanding the mechanisms underlying pathological mechanisms conditions,
Structural analysis, molecular docking and molecular dynamics of an edematogenic lectin from Centrolobium microchaete seeds.
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Lectins represent a class of proteins or glycoproteins capable of reversibly binding to carbohydrates. Seed lectins from the Dalbergieae tribe (Leguminosae) have structural variability, carbohydrate specificity, and biological effects, such as inflammation, vasorelaxation and cancer antigen binding.
Protective effect of polysaccharide from Ligusticum chuanxiong hort against H2O2-induced toxicity in zebrafish embryo.
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A protein-containing polysaccharide, LCP, showing strong antioxidant activity from the rhizome of Ligusticum chuanxiong Hort was fractionated and purified. Its physicochemical properties were characterised by gel permeation chromatography (GPC), gas chromatography-mass spectrometry (GC-MS), UV and
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