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Longitudinally extensive varicella-zoster virus myelitis in a patient with multiple sclerosis.
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METHODS
Case report.
OBJECTIVE
To report this rare varicella-zoster virus (VZV) complication in a patient with multiple sclerosis.
BACKGROUND
Longitudinally extensive transverse myelitis is a spinal cord lesion that extends over 3 or more vertebral segments. A common feature in neuromyelitis optica,
Neuromyelitis optica (NMO) antibody positivity in patients with transverse myelitis and no visual manifestations.
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OBJECTIVE
To describe a subgroup of patients with IgG antibody to Aquaporin 4 Protein (AQP4) specific to neuromyelitis optica (NMO), who did not have clinical manifestations of optic nerve involvement at the time of diagnosis.
METHODS
Assessment of five patients (four African Americans and one
[Case of atopic myelitis with acute onset and atypical distribution of spinal cord lesions].
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A 23-year-old woman was admitted to our department because of gait disturbance, sensory impairment in the lower limbs, and sphincter disturbance, all of which had been developing within 24 hours before admission. Neurological examination disclosed symmetric muscle weakness, sensory impairment, and
Acute flaccid myelitis temporally associated with rhinovirus infection: just a coincidence?
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We report the case of a 3.6-year-old male child who developed progressive hyposthenia of the left lower limb. Symptoms were preceded by rhinitis, malaise, and fever. Brain and spinal magnetic resonance imaging revealed diffuse signal abnormalities compatible with a subacute myeloencephalitis. A
Acute and latent herpes simplex virus neurological disease in mice immunized with purified virus-specific glycoproteins gB or gD.
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Groups of 5-week-old BALB/c mice were immunized intraperitoneally with approximately 10 micrograms of purified alum-precipitated glycoprotein gB or gD of either herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) origin. Control mice received injections of alum-precipitated 1% bovine serum albumin
Severe steroid-resistant post-infectious encephalomyelitis: general features and effects of IVIg.
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Based on their presumed immuno-mediated etiology, post-infectious CNS disorders are commonly treated with high-dose steroids. Factors influencing treatment effectiveness, possible alternative options for steroid-resistant cases, and their outcome profiles, remain unclear. We here describe the
Postinfectious neurologic syndromes: a prospective cohort study.
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OBJECTIVE
Postinfectious neurologic syndromes (PINSs) of the CNS include heterogeneous disorders, sometimes relapsing. In this study, we aimed to a) describe the spectrum of PINSs; b) define predictors of outcome in PINSs; and c) assess the clinical/paraclinical features that help differentiate
Epstein-Barr virus myeloradiculitis and encephalomyeloradiculitis.
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We provide a comprehensive clinical, radiological and virological analysis of four patients with Epstein-Barr virus (EBV) infection of the nervous system. One patient developed acute myeloradiculitis, one had acute encephalomyeloradiculitis, one had acute meningoencephalomyeloradiculitis and one had
[Neurobrucellosis: clinical features and therapeutic responses in 15 patients].
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We report a retrospective analysis of 15 cases of neurobrucellosis. Initial clinical manifestations consisted of meningoencephalitis in 5 patients, acute and subacute meningitis in 4, intracranial hypertension in 2, polyradiculoneuritis with albumin-cell dissociation in 2 (one with cerebral and
Receptor-mediated transport of LIF across blood-spinal cord barrier is upregulated after spinal cord injury.
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Leukemia inhibitory factor (LIF) crosses the normal blood-brain and blood-spinal cord barrier (BBB) by a saturable transport system [Pan, W., Kastin, A.J., Brennan, J.M., 2000. Saturable entry of leukemia inhibitory factor from blood to the central nervous system. J. Neuroimmunol. 106, 172-180].
Anti-C1q autoantibodies in patients with neuromyelitis optica spectrum disorders.
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We examined anti-complement C1q (C1q) autoantibody levels in serum and cerebrospinal fluid (CSF) samples of patients with neuromyelitis optica spectrum disorders (NMOSD). We analyzed the correlations between anti-C1q autoantibody levels and the clinical and other CSF characteristics of NMOSD. Serum
Differential neuro-immune patterns in two clinically relevant murine models of multiple sclerosis.
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Therapeutic Plasma Exchange in Patients with Neurologic Disorders: Review of 63 Cases.
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Therapeutic plasma exchange (TPE) is a procedure that reduces circulating autoantibodies of the patients. TPE is commonly used in neurological disorders where autoimmunity plays a major role. We report our experience with regard to the indications, adverse events and outcomes of plasma exchange in
GRP 78 antibodies are associated with clinical phenotype in neuromyelitis optica.
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High-resolution bimodal imaging and potent antibiotic/photodynamic synergistic therapy for osteomyelitis with a bacterial inflammation-specific versatile agent.
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Unsatisfactory diagnosis and therapy of osteomyelitis are still common but challenging issues for clinicians. To overcome these problems, a bacterial inflammation-specific multifunctional agent, denoted bovine serum albumin-manganese dioxide-ubiquicidin29-41-indocyanine green (ICG)
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